Evidence map›Paper›PMID 26281892›Full record

ReviewNature reviews. Nephrology2015

Kidney-brain crosstalk in the acute and chronic setting.

Renhua Lu, Matthew C Kiernan, Anne Murray, Mitchell H Rosner, Claudio Ronco

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
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  11. Review
  12. Observational
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  15. Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025
    Article
  16. Review
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  18. Article
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Renhua LuDepartment of Nephrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Pu Jian Road 160, 200127 Shanghai, China.
Matthew C KiernanBrain &Mind Research Institute, Sydney Medical School, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.
Anne MurrayDepartment of Medicine, Geriatrics Division, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, USA.
Mitchell H RosnerDivision of Nephrology, University of Virginia Health System, 1215 Lee Street Charlottesville, VA 22908, USA.
Claudio RoncoDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, International Renal Research Institute of Vicenza, Viale Rodolfi 37, 36100 Vicenza, Italy.
Hennepin County Medical Center · USInternational Renal Research Institute of Vicenza · ITRenji Hospital · CNThe University of Sydney · AUUniversity of Virginia Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with kidney disease often exhibit multiple organ dysfunction that is caused, in part, by marked connectivity between the kidney and other organs and tissues. Substantial crosstalk occurs between the kidney and the brain, as indicated by the frequent presentation of neurological disorders, such as cerebrovascular disease, cognitive impairment, and neuropathy during the natural history of chronic kidney disease. The underlying pathophysiology of such comorbid neurological disorders in kidney disease is governed by shared anatomic and vasoregulatory systems and humoral and non-humoral bidirectional pathways that affect both the kidney and the brain. During acute kidney injury, the brain and kidney might interact through the amplification of cytokine-induced damage, extravasation of leukocytes, oxidative stress, and dysregulation of sodium, potassium, and water channels. The advent of dialysis and renal transplantation programmes has led to a reduction in the rate of neurological complications associated with uraemia, but a new set of complications have arisen as a consequence of the effects of dialysis on the central nervous system over the short and long term. This Review discusses the clinical complications of acute and chronic renal failure from a neurologic perspective, and highlights current understanding of the underlying pathophysiologies.

Indexed as

Acute Kidney InjuryBrainBrain DiseasesCerebrovascular DisordersCognition DisordersHumansKidneyKidney Failure, ChronicRenal DialysisRenal Insufficiency, Chronic

Identifiers

PMID26281892
OpenAlexW1937321483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.