ArticleNeurobiology of aging2015
Head west or left, east or right: interactions between memory systems in neurocognitive aging.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Inhibition of histone lysine demethylase restores learning and memory in aged mice.bioRxiv : the preprint server for biology · 2025Article
- Proteins with cognition-associated structural changes in a rat model of aging exhibit reduced refolding capacity.Science advances · 2025Article
- Object-place-context learning impairment correlates with spatial learning impairment in aged Long-Evans rats.Hippocampus · 2024Article
- Muscimol inactivation of dorsal striatum in young and aged male rats does not affect paired associates learning performance.Behavioral neuroscience · 2023Article
- Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation.Frontiers in human neuroscience · 2023Article
- 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022Review
- Resting-State EEG Microstates Parallel Age-Related Differences in Allocentric Spatial Working Memory Performance.Brain topography · 2021Article
- Article
- Age-Related Differences in Resting-State EEG and Allocentric Spatial Working Memory Performance.Frontiers in aging neuroscience · 2021Article
- Exploring the Spatial Relationships Between Real and Virtual Experiences: What Transfers and What Doesn't.Frontiers in virtual reality · 2020Article
- Aging is not equal across memory systems.Neurobiology of learning and memory · 2020Article
- Cardiorespiratory fitness and hippocampal volume predict faster episodic associative learning in older adults.Hippocampus · 2020Article
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- Age-Related Alterations in Prelimbic Cortical NeuronFrontiers in aging neuroscience · 2020Article
- Cortical network dynamics are coupled with cognitive aging in rats.Hippocampus · 2019Article
- Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence.Hippocampus · 2019Article
- Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.eLife · 2019Article
- Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.Neurobiology of aging · 2019Article
- Is PASA Passé?: Rethinking Compensatory Mechanisms in Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity.Neurobiology of aging · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive aging is accompanied by decline in multiple domains of memory. Here, we developed a T-maze task that required rats to learn competing hippocampal, and striatal navigation strategies in succession, across days. A final session increased demands on cognitive flexibility and required within-day switching between strategies, emphasizing capacities that engage the prefrontal cortex. Background characterization in young and aged rats used a water maze protocol optimized for individual differences in hippocampal integrity. Consistent with earlier work, young adults acquired place strategies in the T-maze faster than response, whereas the opposite was observed in aged rats with impaired spatial memory. The novel result was that aged animals with preserved spatial memory displayed a qualitatively distinct pattern, acquiring place and response strategies equally rapidly, without disruption when switching between them. Subsequent in situ hybridization for the plasticity-related immediate-early gene Arc revealed that while increasing demands on cognitive flexibility and within-day strategy switching potently engaged the prefrontal cortex in young adult and aged-impaired rats, Arc expression was insensitive in aged rats with normal spatial memory and superior switching abilities. Together, the results indicate that cognitive aging is an emergent property of the interactions between memory systems, and that successful cognitive outcomes reflect a distinct neuroadaptive process rather than a slower rate of aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.