ArticleEuropean journal of nuclear medicine and molecular imaging2016
Impact of PET/CT image reconstruction methods and liver uptake normalization strategies on quantitative image analysis.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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27 citing papers in PubMed.
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- Quantitative and clinical implications of the EARL2 versus EARL1 [EJNMMI research · 2023Article
- Optimization of BMI-Based Images for Overweight and Obese Patients - Implications on Image Quality, Quantification, and Radiation Dose in Whole BodyNuclear medicine and molecular imaging · 2023Article
- Performance of Deauville Criteria inDiagnostics (Basel, Switzerland) · 2023Article
- Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.NPJ precision oncology · 2021Article
- Moving the goalposts while scoring-the dilemma posed by new PET technologies.European journal of nuclear medicine and molecular imaging · 2021Article
- The effect of reduced scan time on response assessment FDG-PET/CT imaging using Deauville score in patients with lymphoma.European journal of hybrid imaging · 2021Article
- Impact of the Q.Clear reconstruction algorithm on the interpretation of PET/CT images in patients with lymphoma.EJNMMI research · 2020Article
- HYPHYCA: a prospective study in 613 patients conducting a comprehensive analysis for predictive factors of physiologicalEJNMMI research · 2020Article
- Quantitative implications of the updated EARL 2019 PET-CT performance standards.EJNMMI physics · 2019Article
- Time to Prepare for Risk Adaptation in Lymphoma by Standardizing Measurement of Metabolic Tumor Burden.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Test-Retest Reproducibility ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
- Review
- An account of data entry inconsistencies and their impact on positron emission tomography quantification.Medicine · 2018Article
- Metabolic Tumour Volume for Response Prediction in Advanced-Stage Hodgkin Lymphoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- All that glitters is not gold - new reconstruction methods using Deauville criteria for patient reporting.European journal of nuclear medicine and molecular imaging · 2018Article
- EORTC PET response criteria are more influenced by reconstruction inconsistencies than PERCIST but both benefit from the EARL harmonization program.EJNMMI physics · 2017Article
- Impact of the EARL harmonization program on automatic delineation of metabolic active tumour volumes (MATVs).EJNMMI research · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn oncological imaging using PET/CT, the standardized uptake value has become the most common parameter used to measure tracer accumulation. The aim of this analysis was to evaluate ultra high definition (UHD) and ordered subset expectation maximization (OSEM) PET/CT reconstructions for their potential impact on quantification. PATIENTS AND
methodsWe analyzed 40 PET/CT scans of lung cancer patients who had undergone PET/CT. Standardized uptake values corrected for body weight (SUV) and lean body mass (SUL) were determined in the single hottest lesion in the lung and normalized to the liver for UHD and OSEM reconstruction. Quantitative uptake values and their normalized ratios for the two reconstruction settings were compared using the Wilcoxon test. The distribution of quantitative uptake values and their ratios in relation to the reconstruction method used were demonstrated in the form of frequency distribution curves, box-plots and scatter plots. The agreement between OSEM and UHD reconstructions was assessed through Bland-Altman analysis.
resultsA significant difference was observed after OSEM and UHD reconstruction for SUV and SUL data tested (p < 0.0005 in all cases). The mean values of the ratios after OSEM and UHD reconstruction showed equally significant differences (p < 0.0005 in all cases). Bland-Altman analysis showed that the SUV and SUL and their normalized values were, on average, up to 60 % higher after UHD reconstruction as compared to OSEM reconstruction.
conclusionOSEM and HD reconstruction brought a significant difference for SUV and SUL, which remained constantly high after normalization to the liver, indicating that standardization of reconstruction and the use of comparable SUV measurements are crucial when using PET/CT.
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