Evidence map›Paper›PMID 26280980›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2016

Assessment of endothelial function and myocardial flow reserve using (15)O-water PET without attenuation correction.

Stéphane Tuffier, Damien Legallois, Annette Belin, Michael Joubert, Alban Bailliez, Michel Redonnet, Denis Agostini, Alain Manrique

Registry-linked trialAbstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02524574 (Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02524574 nacompletednot on this map

Tomography Positron Emission Assessment of the Impact of Cardiac Rehabilitation on Coronary Endothelial Function in Cardiac Failure

TypeinterventionalSponsorUniversity Hospital, CaenRan2010 to 2015Enrolled54ConditionsCardiac FailureArmscardiac Rehabilitation, Tomography Positron Emission
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Influence of image reconstruction on quantitative cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  3. CardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  4. First validation of myocardial flow reserve assessed by dynamicEuropean journal of nuclear medicine and molecular imaging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stéphane TuffierNormandie Université, EA 4650, Caen, France.
Damien LegalloisNormandie Université, EA 4650, Caen, France.
Annette BelinDepartment of Cardiac Surgery, Caen University Hospital, Caen, France.
Michael JoubertNormandie Université, EA 4650, Caen, France.
Alban BailliezNormandie Université, EA 4650, Caen, France.
Michel RedonnetDepartment of Cardiac Surgery, Rouen University Hospital, Rouen, France.
Denis AgostiniNormandie Université, EA 4650, Caen, France.
Alain ManriqueNormandie Université, EA 4650, Caen, France. manrique@cyceron.fr.
Normandie Université · FRUniversité de Caen Normandie · FRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMyocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of (15)O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and myocardial flow reserve (MFR) using (15)O-water PET.

methodsWe retrospectively processed 70 consecutive (15)O-water PET examinations obtained at rest and during cold pressor testing (CPT) in patients with dilated cardiomyopathy (n = 58), or at rest and during adenosine infusion in heart transplant recipients (n = 12). Data were reconstructed with attenuation correction (AC) and without attenuation correction (NAC) using filtered backprojection, and MBF was quantified using a single compartmental model. The agreement between AC and NAC data was assessed using Lin's concordance correlation coefficient followed by Bland-Altman plot analysis.

resultsRegarding endothelial function, NAC PET showed poor reproducibility and poor agreement with AC PET data. Conversely, NAC PET demonstrated high reproducibility and a strong agreement with AC PET for the assessment of MFR.

conclusionNon-attenuation-corrected (15)O-water PET provided an accurate measurement of MFR compared to attenuation-corrected PET. However, non-attenuation-corrected PET data were less effective for the assessment of endothelial function using CPT in this population.

Indexed as

Fractional Flow Reserve, MyocardialImage Processing, Computer-AssistedPositron-Emission TomographyAdultAgedCardiomyopathy, DilatedEndothelium, VascularFemaleHumansMaleMiddle AgedOxygen RadioisotopesRadiopharmaceuticalsReproducibility of ResultsOxygen RadioisotopesRadiopharmaceuticals15O-waterAttenuation correctionEndothelial functionMyocardial flow reserveMyocardial perfusionPositron emission tomography

Identifiers

PMID26280980
OpenAlexW2163884487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.