ArticleNature genetics2015
Absence of canonical marks of active chromatin in developmentally regulated genes.
Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
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- Sunflower seed-specific HSFA9 induces persistent chromatin accessibility during seed-to-seedling developmental transition.The Plant journal : for cell and molecular biology · 2025Article
- Targeting mCurrent oncology (Toronto, Ont.) · 2025Review
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- ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-β signaling pathway.Cell death and differentiation · 2023Article
- Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity.Nucleic acids research · 2023Article
- CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.Science advances · 2023Article
- Epigenomic signatures on paralogous genes reveal underappreciated universality of active histone codes adopted across animals.Computational and structural biotechnology journal · 2022Article
- The epigenetic origin of life history transitions in plants and algae.Plant reproduction · 2021Review
- An explainable artificial intelligence approach for decoding the enhancer histone modifications code and identification of novel enhancers in Drosophila.Genome biology · 2021Article
- Productive visualization of high-throughput sequencing data using the SeqCode open portable platform.Scientific reports · 2021Article
- Chromatin Organization and Function inCells · 2021Review
- Enhancers with tissue-specific activity are enriched in intronic regions.Genome research · 2021Article
- Parental nucleosome segregation and the inheritance of cellular identity.Nature reviews. Genetics · 2021Review
- Histone acetylation dynamics modulates chromatin conformation and allele-specific interactions at oncogenic loci.Nature genetics · 2021Article
- Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.Cell systems · 2020Article
- Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation.Nature genetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.