Effects of preoperative and intraoperative glucose administration on glucose use and fat catabolism during laparotomy under sevoflurane anesthesia in fasted rats.

Yoshiteru Mori, Takayuki Kitamura, Gaku Kawamura, Kanako Sato, Rui Sato, Yuko Araki, Yoshitsugu Yamada

Erratum issuedOpen access · goldAbstract read

In one paragraph

Article in The journal of physiological sciences : JPS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 37% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

Effects of preoperative oral carbohydrate intake on catabolism, nutrition and adipocytokines during minor surgery: A randomized, prospective, controlled clinical phase II trial.PloS one · 2019
Trial
Blood Glucose and Triglyceride Changes Following the Administration of Commercial Enteral Nutrition Solutions with Differing Glucose and Fat Contents.Journal of the ASEAN Federation of Endocrine Societies · 2025
Article

4 · The record

Corrections and comments

Erratum issued
Erratum to: Effects of preoperative and intraoperative glucose administration on glucose use and fat catabolism during laparotomy under sevoflurane anesthesia in fasted rats.2015

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yoshiteru MoriDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Takayuki KitamuraDepartment of Anesthesiology, Toho University Sakura Medical Center, Sakura, Chiba, Japan.

Gaku KawamuraDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. gaku-kawa@umin.ac.jp.

Kanako SatoDepartment of Anesthesiology, Toho University Sakura Medical Center, Sakura, Chiba, Japan.

Rui SatoDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Yuko ArakiDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Yoshitsugu YamadaDepartment of Anesthesiology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

The University of Tokyo · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative fasting as well as surgical stress significantly modifies metabolisms. Recent studies reported the possible advantageous effects of glucose administration on perioperative metabolisms; however, the underlying mechanisms have not been fully elucidated. Rats were allocated to three groups. During the fasting period, groups A and B were administered water, but group C was administered glucose. During laparotomy and the insulin tolerance test (ITT) under sevoflurane anesthesia, group A was administered saline, but groups B and C were administered glucose. During laparotomy, group C showed higher glucose levels and lower β-hydroxybutyrate (β-OHB) levels than group A, and group B showed more decreases in β-OHB levels than group A without differences in changes in glucose levels. Insulin levels and insulin sensitivity during laparotomy were similar among the three groups. No significant difference in insulin sensitivity was also confirmed in ITT. In conclusion, perioperative glucose administration suppresses lipolysis without affecting insulin secretion and sensitivity.

Indexed as

LaparotomyAdipose TissueAnesthetics, InhalationAnimalsBlood GlucoseFood DeprivationGlucoseInsulinIntraoperative PeriodMaleMethyl EthersPreoperative PeriodRatsRats, WistarSevofluraneAnesthetics, InhalationBlood GlucoseGlucoseInsulinMethyl EthersSevofluraneAdipocytokineInsulin secretionInsulin sensitivityIntraoperative glycemic controlβ-Hydroxybutyrate

Identifiers

PMID26280893

DOI10.1007/s12576-015-0390-7

PMCPMC10717368

OpenAlexW4243399521

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.