Evidence map›Paper›PMID 26280823›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2015

Effect of Extra Virgin Olive Oil on Biomarkers of Inflammation in HIV-Infected Patients: A Randomized, Crossover, Controlled Clinical Trial.

Sanja Kozić Dokmanović, Krunoslava Kolovrat, Renata Laškaj, Vedrana Jukić, Nada Vrkić, Josip Begovac

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427760 (Effect of Using Oxygen on the Diaper Dermatitis in Infants), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05427760 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Using Oxygen on the Diaper Dermatitis in Infants

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2022 to 2023Enrolled103ConditionsDiaper Rash, Diaper DermatitisArmsOxygen
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sanja Kozić DokmanovićDepartment for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.
Krunoslava KolovratDepartment for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.
Renata LaškajDepartment for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.
Vedrana JukićDepartment for Biochemistry and Hematology, University Hospital for Infectious Diseases "Dr Fran Mihaljević", Zagreb, Croatia.
Nada VrkićDepartment of Medical Biochemistry and Haematology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
Josip BegovacOutpatient Department for HIV Infection, University Hospital for Infectious Diseases "Dr Fran Mihaljević", University of Zagreb, School of Medicine, Zagreb, Croatia.
University of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPremature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART. MATERIAL AND

methodsThis randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively.

resultsIn participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration.

conclusionsOur exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

Indexed as

AdolescentAdultAgedAntiretroviral Therapy, Highly ActiveAtherosclerosisBiomarkersC-Reactive ProteinCross-Over StudiesDrug CombinationsFood HandlingHIV InfectionsHIV Protease InhibitorsHumansInflammation MediatorsLopinavirMaleBiomarkersC-Reactive ProteinDrug CombinationsHIV Protease InhibitorsInflammation MediatorsLopinavirlopinavir-ritonavir drug combinationOlive OilRitonavir

Identifiers

PMID26280823
PMCPMC4544351
OpenAlexW2255574533

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.