Evidence map›Paper›PMID 26280330›Full record

ArticleNature methods2015

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice.

Kate L Montgomery, Alexander J Yeh, John S Ho, Vivien Tsao, Shrivats Mohan Iyer, Logan Grosenick, Emily A Ferenczi, Yuji Tanabe, Karl Deisseroth, Scott L Delp and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Optogenetic control of the enteric nervous system and gastrointestinal transit.Expert review of gastroenterology & hepatology · 2019
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kate L MontgomeryDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Alexander J YehDepartment of Electrical Engineering, Stanford University, Stanford, California, USA.
John S HoDepartment of Electrical Engineering, Stanford University, Stanford, California, USA.
Vivien TsaoDepartment of Electrical Engineering, Stanford University, Stanford, California, USA.
Shrivats Mohan IyerDepartment of Bioengineering, Stanford University, Stanford, California, USA.ORCID http://orcid.org/0000-0003-4648-3637
Logan GrosenickDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Emily A FerencziDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Yuji TanabeDepartment of Electrical Engineering, Stanford University, Stanford, California, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Scott L DelpDepartment of Bioengineering, Stanford University, Stanford, California, USA.
Ada S Y PoonDepartment of Electrical Engineering, Stanford University, Stanford, California, USA.

Funding

Optogenetic inhibition of motor neuron and muscle activity in vivoR01NS080954 · NINDS · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2012 to 2015
$1.3M
NINDS NIH HHS R01 NS080954NINDS NIH HHS R01-NS080954
6 · The paper itself

Abstract

To enable sophisticated optogenetic manipulation of neural circuits throughout the nervous system with limited disruption of animal behavior, light-delivery systems beyond fiber optic tethering and large, head-mounted wireless receivers are desirable. We report the development of an easy-to-construct, implantable wireless optogenetic device. Our smallest version (20 mg, 10 mm(3)) is two orders of magnitude smaller than previously reported wireless optogenetic systems, allowing the entire device to be implanted subcutaneously. With a radio-frequency (RF) power source and controller, this implant produces sufficient light power for optogenetic stimulation with minimal tissue heating (<1 °C). We show how three adaptations of the implant allow for untethered optogenetic control throughout the nervous system (brain, spinal cord and peripheral nerve endings) of behaving mice. This technology opens the door for optogenetic experiments in which animals are able to behave naturally with optogenetic manipulation of both central and peripheral targets.

Indexed as

Implants, ExperimentalWireless TechnologyAnimalsBrainEquipment DesignFemaleLightMice, Inbred C57BLMice, TransgenicMiniaturizationMotor CortexNociceptorsOptogeneticsPeripheral NervesSpinal CordTemperature

Identifiers

PMID26280330
PMCPMC5507210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.