Trial reportJournal of endocrinological investigation2016
The correlation of resistance exercise-induced myostatin with insulin resistance and plasma cytokines in healthy young men.
Trial report in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05573321 (Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Two-Way Communication Between Skeletal Muscle and Myokines.Cell biochemistry and function · 2026Review
- Exercise Intensity and Circulating Exerkine Responses: A Narrative Review of Selected Molecules.Biomolecules · 2026Review
- Myostatin Research: From Molecular Understanding to Clinical Translation for Musculoskeletal and Metabolic Disorders.International journal of molecular sciences · 2026Review
- The decorin and myostatin response to acute whole body vibration: impact of adiposity, sex, and race.International journal of obesity (2005) · 2024Article
- How Can Promoting Skeletal Muscle Health and Exercise in Children and Adolescents Prevent Insulin Resistance and Type 2 Diabetes?Life (Basel, Switzerland) · 2024Review
- Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance.Journal of cachexia, sarcopenia and muscle · 2024Review
- Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers.Pflugers Archiv : European journal of physiology · 2024Article
- Myostatin and the Heart.Biomolecules · 2023Review
- High-intensity circuit training change serum myostatin but not myogenin in adolescents' soccer players: a quasi-experimental study.BMC sports science, medicine & rehabilitation · 2023Article
- Myokines and Resistance Training: A Narrative Review.International journal of molecular sciences · 2022Review
- The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism.Frontiers in physiology · 2022Review
- Cell Types Used for Cultured Meat Production and the Importance of Myokines.Foods (Basel, Switzerland) · 2021Review
- Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People.International journal of environmental research and public health · 2021Review
- Short-Term Resistance Training Supported by Whole-Body Cryostimulation Induced a Decrease in Myostatin Concentration and an Increase in Isokinetic Muscle Strength.International journal of environmental research and public health · 2020Article
- Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective.Current diabetes reports · 2020Review
- Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.Comprehensive Physiology · 2020Review
- Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition.Scientific reports · 2020Article
- Role of Myokines in Regulating Skeletal Muscle Mass and Function.Frontiers in physiology · 2019Review
- Sport and male sexuality.Journal of endocrinological investigation · 2017Review
- Comparable Effects of Brief Resistance Exercise and Isotime Sprint Interval Exercise on Glucose Homeostasis in Men.Journal of diabetes research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was designed to examine the correlation of resistance exercise (RE)-induced myostatin (MSTN) with insulin resistance and plasma cytokines in healthy young men.
methodsTwenty-four healthy men were randomly divided into RE (n = 12) and control (n = 12) group. After a session of familiarization, one repetition maximum (1-RM) was calculated. Circuit RE program involved 3 sets of 15 repetitions at 55 % of 1-RM. Blood samples were collected before and 24 h after the exercise. Paired t test, independent t test, and Pearson's correlation were used for analyzing data.
resultsA significant decrease in plasma level of MSTN, glucose, insulin, interleukin-6 (IL-6), and homeostasis model assessment of insulin resistance (HOMA-IR) and a significant increase in plasma interleukin-10 (IL-10) were found in RE group 24 h post-exercise versus pre-exercise (p < 0.05). Furthermore, except plasma IL-10, a significant decrease in metabolic variables was found in RE group versus control group (p < 0.05). A significantly positive correlation of plasma MSTN with HOMA-IR and plasma IL-6 and a significantly negative correlation of plasma MSTN with plasma IL-10 were found in RE group versus control group (p < 0.05).
conclusionsIt seems that a circuit RE bout by reducing HOMA-IR and changing plasma cytokines (decreased IL-6 and increased IL-10) can decrease plasma level of MSTN in healthy young men. In other word, the beneficial effect of acute RE may be reflected by changes in MSTN in healthy young individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.