Evidence map›Paper›PMID 26280298›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2015

Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation.

Naomi M Scott, Royce L X Ng, Terence A McGonigle, Shelley Gorman, Prue H Hart

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Naomi M ScottTelethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Royce L X NgTelethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Terence A McGonigleTelethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Shelley GormanTelethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Prue H HartTelethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia. Prue.Hart@telethonkids.org.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDuring respiratory inflammation, it is generally assumed that dendritic cells differentiating from the bone marrow are immunogenic rather than immunoregulatory. Using chimeric mice, the outcomes of airways inflammation on bone marrow progenitor cells were studied.

methodsImmune responses were analyzed in chimeric mice engrafted for >16 weeks with bone marrow cells from mice with experimental allergic airways disease (EAAD).

resultsResponses to sensitization and challenge with the allergen causing inflammation in the bone marrow-donor mice were significantly reduced in the chimeric mice engrafted with bone marrow cells from mice with EAAD (EAAD-chimeric). Responses to intranasal LPS and topical fluorescein isothiocyanate (non-specific challenges) were significantly attenuated. Fewer activated dendritic cells from the airways and skin of the EAAD-chimeric mice could be tracked to the draining lymph nodes, and may contribute to the significantly reduced antigen/chemical-induced hypertrophy in the draining nodes, and the reduced immune responses to sensitizing allergens. Dendritic cells differentiating in vitro from the bone marrow of >16 weeks reconstituted EAAD-chimeric mice retained an ability to poorly prime immune responses when transferred into naïve mice.

conclusionsDendritic cells developing from bone marrow progenitors during airways inflammation are altered such that daughter cells have reduced antigen priming capabilities.

Indexed as

Administration, IntranasalAdoptive TransferAnimalsAzacitidineBone Marrow CellsBronchoalveolar Lavage FluidCell CountDecitabineDendritic CellsDisease Models, AnimalDNA Modification MethylasesFemaleFluorescein-5-isothiocyanateFluorescent DyesImmunoglobulin EImmunoglobulin GAzacitidineDecitabineDNA Modification MethylasesFluorescein-5-isothiocyanateFluorescent DyesImmunoglobulin EImmunoglobulin GLipopolysaccharidesOrganic ChemicalsOvalbuminPKH 26Bone marrowChimeric miceDendritic cellsImmunoregulatoryRespiratory inflammation

Identifiers

PMID26280298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.