Trial reportNeurosurgery2015
Elevated Baseline C-Reactive Protein as a Predictor of Outcome After Aneurysmal Subarachnoid Hemorrhage: Data From the Simvastatin in Aneurysmal Subarachnoid Hemorrhage (STASH) Trial.
Trial report in Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Associations between C-reactive protein and white blood cell count, occurrence of delayed cerebral ischemia and poor outcome following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.Acta neurologica Belgica · 2021Pooled it
- Outcome prediction in aneurysmal subarachnoid hemorrhage with world federation of neurological societies grade V (OPAS-V).Acta neurochirurgica · 2025Observational
- Serum C-reactive protein value on day 14 as a possible prognostic factor of aneurysmal subarachnoid hemorrhage.The Journal of international medical research · 2024Article
- In-Hospital Risk Factors and Short-Term Outcomes for Subarachnoid Hemorrhage.International journal of general medicine · 2024Article
- Outcomes following poor-grade aneurysmal subarachnoid haemorrhage: a prospective observational study.Acta neurochirurgica · 2023Observational
- Biomarkers in aneurysmal subarachnoid hemorrhage: A short review.World neurosurgery: X · 2023Review
- Clinical relevance of serum procalcitonin in patients with aneurysmal subarachnoid hemorrhage.Experimental and therapeutic medicine · 2022Article
- Lactate dehydrogenase predicting mortality in patients with aneurysmal subarachnoid hemorrhage.Annals of clinical and translational neurology · 2022Observational
- Prognostic Value of C-Reactive Protein and Albumin in Neurocritically Ill Patients with Acute Stroke.Journal of clinical medicine · 2022Article
- C-reactive protein elevation predicts in-hospital deterioration after aneurysmal subarachnoid hemorrhage: a retrospective observational study.Acta neurochirurgica · 2022Observational
- The Role of Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Context of Aneurysmal Subarachnoid Hemorrhage (aSAH)-A Prospective Observational Study.Frontiers in neurology · 2022Article
- Risk factors and predictive models of poor prognosis and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage complicated with hydrocephalus.Frontiers in neurology · 2022Article
- Clinical usefulness of early serial measurements of C-reactive protein as outcome predictors in patients with subarachnoid hemorrhage.BMC neurology · 2020Observational
- Malnutrition in Stroke Patients: Risk Factors, Assessment, and Management.Neurocritical care · 2018Review
- Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal subarachnoid hemorrhage.Journal of neurology · 2018Article
- Acute-Phase Plasma Osteopontin as an Independent Predictor for Poor Outcome After Aneurysmal Subarachnoid Hemorrhage.Molecular neurobiology · 2018Article
- Systemic inflammatory response syndrome, infection, and outcome in intracerebral hemorrhage.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study.Neural regeneration research · 2017Article
- Factors associated with fatal outcome in posterior reversible encephalopathy syndrome: a retrospective analysis of the Berlin PRES study.Journal of neurology · 2017Article
- Association between systemic inflammation biomarkers and outcomes in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurologyArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThere remains a proportion of patients with unfavorable outcomes after aneurysmal subarachnoid hemorrhage, of particular relevance in those who present with a good clinical grade. A forewarning of those at risk provides an opportunity towards more intensive monitoring, investigation, and prophylactic treatment prior to the clinical manifestation of advancing cerebral injury.
objectiveTo assess whether biochemical markers sampled in the first days after the initial hemorrhage can predict poor outcome.
methodsAll patients recruited to the multicenter Simvastatin in Aneurysmal Hemorrhage Trial (STASH) were included. Baseline biochemical profiles were taken between time of ictus and day 4 post ictus. The t-test compared outcomes, and a backwards stepwise binary logistic regression was used to determine the factors providing independent prediction of an unfavorable outcome.
resultsBaseline biochemical data were obtained in approximately 91% of cases from 803 patients. On admission, 73% of patients were good grade (World Federation of Neurological Surgeons grades 1 or 2); however, 84% had a Fisher grade 3 or 4 on computed tomographic scan. For patients presenting with good grade on admission, higher levels of C-reactive protein, glucose, and white blood cells and lower levels of hematocrit, albumin, and hemoglobin were associated with poor outcome at discharge. C-reactive protein was found to be an independent predictor of outcome for patients presenting in good grade.
conclusionEarly recording of C-reactive protein may prove useful in detecting those good grade patients who are at greater risk of clinical deterioration and poor outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.