ArticleAmerican journal of translational research2015
Different localization and expression of protein kinase C-beta in kidney cortex of diabetic nephropathy mice and its role in telmisartan treatment.
Article in American journal of translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease.Journal of diabetes research · 2017Review
- Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney.International journal of endocrinology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aims to investigate the localization and expression of protein kinase C-beta I and beta II in kidney cortex of diabetic nephropathy mice and their roles in telmisartan treatment.
methods18 mice were randomly divided into three groups: normal group, diabetic nephropathy group and telmisartan-treated group. The localization and expression of protein kinase C-beta I and beta II were measured with confocal immunofluorescence laser scanning microscopy, immunohistochemistry and western blotting. The expression of transforming growth factor-beta 1 and vascular endothelial growth factor in glomeruli was detected by immunohistochemistry.
resultsCompared to the normal mice, the expression and localization of protein kinase C-beta I and beta II are differed in diabetic nephropathy mice, with increased expression of protein kinase C-beta I but decreased level of protein kinase C-beta II. Meanwhile, the expression of transforming growth factor-beta 1 and vascular endothelial growth factor showed increase in the glomeruli of diabetic nephropathy, compared to the controls. Also, protein kinase C-beta I exhibited a positive correlation to transforming growth factor-beta 1 (r = 0.649, P = 0.030), but no correlation to vascular endothelial growth factor (r = 0.387, P = 0.079). Telmisartan treatment exercised significant beneficial role in diabetic nephropathy, which is associated with protein kinase C-beta I, but not beta II.
conclusionsThe expression and localization of protein kinase C-beta I and beta II differ in the diabetic nephropathy, and such difference is associated with the pathogeneses of diabetic nephropathy.
Indexed as
Identifiers
26279755PMC4532744W2411132045What OpenQuestion holds
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