ArticleWorld journal of emergency surgery : WJES2015
Trauma resuscitation requiring massive transfusion: a descriptive analysis of the role of ratio and time.
Article in World journal of emergency surgery : WJES, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dynamic impact of transfusion ratios on outcomes in severely injured patients: Targeted machine learning analysis of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios randomized clinical trial.The journal of trauma and acute care surgery · 2020Trial
- Association between intraoperative blood transfusion and postoperative delirium in elderly patients undergoing total hip arthroplasty with combined spinal-epidural anesthesia: an IPTW-adjusted retrospective cohort study.BMC anesthesiology · 2025Article
- Implementation of a massive transfusion protocol: A single trauma center experience from South Korea.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Association of Early, High Plasma-to-Red Blood Cell Transfusion Ratio With Mortality in Adults With Severe Bleeding After Trauma.JAMA network open · 2019Article
- Shock index in patients with traumatic solid organ injury as a predictor of massive blood transfusion protocol activation.Injury epidemiology · 2019Article
- Article
- Review of transfusion practices and its outcome in trauma patients at an urban level 1 trauma center in India.Asian journal of transfusion scienceArticle
- Early high ratio platelet transfusion in trauma resuscitation and its outcomes.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to evaluate whether early administration of high plasma to red blood cells ratios influences outcomes in injured patients who received massive transfusion protocol (MTP).
methodsA retrospective analysis was conducted at the only level 1 national trauma center in Qatar for all adult patients(≥18 years old) who received MTP (≥10 units) of packed red blood cell (PRBC) during the initial 24 h post traumatic injury. Data were analyzed with respect to FFB:PRBC ratio [(high ≥ 1:1.5) (HMTP) vs. (low < 1:1.5) (LMTP)] given at the first 4 h post-injury and also between (>4 and 24 h). Mortality, multiorgan failure (MOF) and infectious complications were studied as well.
resultsDuring the study period, a total of 4864 trauma patients were admitted to the hospital, 1.6 % (n = 77) of them met the inclusion criteria. Both groups were comparable with respect to initial pH, international normalized ratio, injury severity score, revised trauma score and development of infectious complications. However, HMTP was associated with lower crude mortality (41.9 vs. 78.3 %, p = 0.001) and lower rate of MOF (48.4 vs. 87.0 %, p = 0.001). The number of deaths was 3 times higher in LMTP in comparison to HMTP within the first 30 days (36 vs. 13 cases). The majority of deaths occurred within the first 24 h (80.5 % in LMTP and 69 % in HMTP) and particularly within the first 6 h (55 vs. 46 %).
conclusionsAggressive attainment of high FFP/PRBC ratios as early as 4 h post-injury can substantially improve outcomes in trauma patients.
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