ArticleInternational journal of radiation oncology, biology, physics2015
Effects of Surgery and Proton Therapy on Cerebral White Matter of Craniopharyngioma Patients.
Article in International journal of radiation oncology, biology, physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Combined surgery and proton radiotherapy in the management of craniopharyngiomas: an update with paradigmatic and challenging case scenarios.Neurosurgical review · 2026Article
- Impact of substructure radiation dose on health-related quality of life in children with brain tumors: a Pediatric Proton/Photon Consortium Registry (PPCR) study.Journal of neuro-oncology · 2025Article
- Characterizing long-term neurocognitive outcomes through diffusion tensor imaging in childhood brain tumor survivors.Neuro-oncology · 2025Article
- The role of particle radiotherapy in the treatment of skull base tumors.Frontiers in oncology · 2023Review
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- White matter tract changes in pediatric posterior fossa brain tumor survivors after surgery and chemotherapy.Frontiers in neuroimaging · 2022Article
- Association Between Brain Substructure Dose and Cognitive Outcomes in Children With Medulloblastoma Treated on SJMB03: A Step Toward Substructure-Informed Planning.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging.Endocrine · 2021Article
- Spectrum of neuroimaging findings post-proton beam therapy in a large pediatric cohort.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Retrospective study of late radiation-induced damages after focal radiotherapy for childhood brain tumors.PloS one · 2021Article
- Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma.European journal of endocrinology · 2018Article
- Long-term effects of radiation therapy on white matter of the corpus callosum: a diffusion tensor imaging study in children.Pediatric radiology · 2017Article
- Pathological and Topographical Classification of Craniopharyngiomas: A Literature Review.Journal of neurological surgery reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to determine radiation dose effect on the structural integrity of cerebral white matter in craniopharyngioma patients receiving surgery and proton therapy. METHODS AND MATERIALS: Fifty-one patients (2.1-19.3 years of age) with craniopharyngioma underwent surgery and proton therapy in a prospective therapeutic trial. Anatomical magnetic resonance images acquired after surgery but before proton therapy were inspected to identify white matter structures intersected by surgical corridors and catheter tracks. Longitudinal diffusion tensor imaging (DTI) was performed to measure microstructural integrity changes in cerebral white matter. Fractional anisotropy (FA) derived from DTI was statistically analyzed for 51 atlas-based white matter structures of the brain to determine radiation dose effect. FA in surgery-affected regions in the corpus callosum was compared to that in its intact counterpart to determine whether surgical defects affect radiation dose effect.
resultsSurgical defects were seen most frequently in the corpus callosum because of transcallosal resection of tumors and insertion of ventricular or cyst catheters. Longitudinal DTI data indicated reductions in FA 3 months after therapy, which was followed by a recovery in most white matter structures. A greater FA reduction was correlated with a higher radiation dose in 20 white matter structures, indicating a radiation dose effect. The average FA in the surgery-affected regions before proton therapy was smaller (P=.0001) than that in their non-surgery-affected counterparts with more intensified subsequent reduction of FA (P=.0083) after therapy, suggesting that surgery accentuated the radiation dose effect.
conclusionsDTI data suggest that mild radiation dose effects occur in patients with craniopharyngioma receiving surgery and proton therapy. Surgical defects present at the time of proton therapy appear to accentuate the radiation dose effect longitudinally. This study supports consideration of pre-existing surgical defects and their locations in proton therapy planning and studies of treatment effect.
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