ArticleThe Journal of veterinary medical science2016
A pathological study of the salivary glands of rabid dogs in the Philippines.
Article in The Journal of veterinary medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Pathological Study on Trigeminal Ganglionitis Among Rabid Dogs in the Philippines.Veterinary sciences · 2025Article
- Histopathological and immunohistochemical examination of the brains of rabid dogs in the Philippines.The Journal of veterinary medical science · 2024Article
- Transcriptome analysis of salivary glands of rabies-virus-infected mice.Frontiers in microbiology · 2024Article
- Immunohistochemical detection of virus antigen in the nasal planum of rabid dogs.The Journal of veterinary medical science · 2021Article
- Follicle-sinus complexes in muzzle skin of domestic and wild animals as diagnostic material for detection of rabies.The Journal of veterinary medical science · 2020Article
- Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies.The Journal of veterinary medical science · 2019Article
- Comparative Tandem Mass Tag-Based Quantitative Proteomic Analysis ofFrontiers in cellular and infection microbiology · 2019Article
- Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs.The Journal of veterinary medical science · 2018Article
- Pathological lesions in the central nervous system and peripheral tissues of ddY mice with street rabies virus (1088 strain).The Journal of veterinary medical science · 2017Article
- Article
- Canine Trichomonas tenax mandibular gland infestation.Acta veterinaria Scandinavica · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands are important as exit and propagation sites for the rabies virus, the mechanisms of rabies excretion remain unclear. Here, we investigated the histopathology of the salivary glands of rabid dogs and analyzed the mechanism of excretion into the oral cavity. Mandibular and parotid glands of 22 rabid dogs and three control dogs were used. Mild to moderate non-suppurative sialadenitis was observed in the mandibular glands of 19 of the 22 dogs, characterized by loss of acinar epithelium and infiltration by lymphoplasmacytic cells. Viral antigens were detected in the mucous acinar epithelium, ganglion neurons and myoepithelium. Acinar epithelium and lymphocytes were positive for anti-caspase-3 antibodies and TUNEL staining. In contrast, no notable findings were observed in the ductal epithelial cells and serous demilune. In the parotid gland, the acinar cells, myoepithelium and ductal epithelium all tested negative. These findings confirmed the path through which the rabies virus descends along the facial nerve after proliferation in the brain to reach the ganglion neurons of the mandibular gland, subsequently traveling to the acinar epithelium via the salivary gland myoepithelium. Furthermore, the observation that nerve endings passing through the myoepithelium were absent from the ductal system suggested that viral proliferation and cytotoxicity could not occur there, ensuring that secretions containing the virus are efficiently excreted into the oral cavity.
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