Evidence map›Paper›PMID 26278788›Full record

ArticleScientific reports2015

DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis.

Qi Liu, Cheng-Hu Hu, Cui-Hong Zhou, Xiao-Xia Cui, Kun Yang, Chao Deng, Jia-Jia Xia, Yan Wu, Lu-Chuan Liu, Yan Jin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Qi Liu1] Department of stomatology, Daping hospital, Research institute of Field surgery, Third military medical university, Chongqing, 400042, China [2] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China [3] Department of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Cheng-Hu Hu1] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China [2] Xi'an Institute of Tissue Engineering &Regenerative Medicine, Shaanxi 710032, China.
Cui-Hong Zhou1] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China [2] Xi'an Institute of Tissue Engineering &Regenerative Medicine, Shaanxi 710032, China.
Xiao-Xia CuiDepartment of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Kun YangDepartment of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Chao DengDepartment of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Jia-Jia XiaDepartment of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Yan WuDepartment of Periodontology, Stomatological hospital, Zunyi medical college, Zunyi, Guizhou 563003, China.
Lu-Chuan LiuDepartment of stomatology, Daping hospital, Research institute of Field surgery, Third military medical university, Chongqing, 400042, China.
Yan Jin1] State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China [2] Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, Shaanxi 710032, China [3] Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Zunyi Medical University · CNAir Force Medical University · CNDaping Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple studies have shown that diabetes mellitus is an established risk factor for periodontitis. Recently mesenchymal stem cells derived from periodontal ligament (PDLSCs) have been utilized to reconstruct tissues destroyed by chronic inflammation. However, impact of periodontitis with diabetes mellitus on PDLSCs and mechanisms mediating effects of complex microenvironments remain poorly understood. In this study, we found multiple differentiation potential of PDLSCs from chronic periodontitis with diabetes mellitus donors (D-PDLSCs) was damaged significantly. Inhibition of NF-κB signaling could rescue osteogenic potential of PDLSCs from simple chronic periodontitis patients (P-PDLSCs), whereas did not promote D-PDLSCs osteogenesis. In addition, we found expression of DKK1 in D-PDLSCs did not respond to osteogenic signal and decreased osteogenic potential of D-PDLSCs treated with DKK1 could be reversed. To further elucidate different character between P-PDLSCs and D-PDLSCs, we treated PDLSCs with TNF-α and advanced glycation end products (AGEs), and find out AGEs which enhance effect of TNF-α in PDLSCs might mediate special personality of D-PDLSCs. The adverse effect of AGEs in PDLSCs could be reversed when PDLSCs were treated with DKK1. These results suggested DKK1 mediating WNT signaling might be a therapy target to rescue potential of PDLSCs in periodontitis with diabetes mellitus.

Indexed as

AdultAgedAnimalsbeta CateninCell DifferentiationCells, CulturedCore Binding Factor Alpha 1 SubunitDiabetes Mellitus, Type 2Glycation End Products, AdvancedHumansIntercellular Signaling Peptides and ProteinsMaleMesenchymal Stem CellsMiceMice, Inbred NODMice, SCIDbeta CateninCore Binding Factor Alpha 1 SubunitDKK1 protein, humanGlycation End Products, AdvancedIntercellular Signaling Peptides and ProteinsNF-kappa BTransforming Growth Factor beta

Identifiers

PMID26278788
PMCPMC4538385
OpenAlexW1474372810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.