Evidence map›Paper›PMID 26278503›Full record

ArticleGastroenterology2015

Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.

Chengrui Huang, Talin Haritunians, David T Okou, David J Cutler, Michael E Zwick, Kent D Taylor, Lisa W Datta, Joseph C Maranville, Zhenqiu Liu, Shannon Ellis and 44 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. IL-12 and IL-23 pathway inhibition in inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  16. Multi-omics in Crohn's disease: New insights from inside.Computational and structural biotechnology journal · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Role of Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn's Disease.Evidence-based complementary and alternative medicine : eCAM · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 2 countries.

Chengrui Huang *Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA.
Talin Haritunians *F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
David T Okou *Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
David J CutlerDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Michael E ZwickDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences and Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA,90502, USA.
Lisa W DattaMeyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Joseph C MaranvilleCommittee on Clinical Pharmacology and Pharmacogenomics, and the Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Zhenqiu LiuF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
Shannon EllisMeyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Pankaj ChopraDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jonathan S AlexanderDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Robert N BaldassanoDivision of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Raymond K CrossDivision of Gastroenterology, University of Maryland, Baltimore, MD 21201, USA.
Themistocles DassopoulosDepartment of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Tanvi A DhereDepartment of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Richard H DuerrDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, and Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
John S HansonCharlotte Gastroenterology and Hepatology, PLLC, Charlotte, NC 28207, USA.
Jason K HouDepartment of Medicine, Baylor College of Medicine; VA HSR&D Center for Innovations in Quality, Effectiveness and Safety , Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
Sunny Z HussainDepartment of Pediatrics, Willis-Knighton Physician Network, Shreveport, LA 71118, USA.
Kim L IsaacsDivision of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Kelly E KachelriesDivision of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Howard KaderDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Michael D KappelmanDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Jeffrey KatzDivision of Gastroenterology, Case Western Reserve University, Cleveland, OH 44106, USA.
Richard KellermayerSection of Pediatric Gastroenterology, Baylor College of Medicine, Houston, TX, 77030.
Barbara S KirschnerDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, USA.
John F KuemmerleDepartments of Medicine and Physiology and Biophysics, VCU Program in Enteric Neuromuscular Sciences, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond VA 23298, USA.
Archana KumarDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
John H KwonSection of Gastroenterology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Mark LazarevMeyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Peter MannonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Dedrick E MoultonDivision of Gastroenterology, Vanderbilt Children's Hospital, Nashville TN 37212, USA.
Bankole O OsuntokunDepartment of Pediatrics, Cook Children's Medical Center, Fort Worth, TX 76104, USA.
Ashish PatelDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
John D RiouxUniversite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Quebec H1T 1C8, Canada.
Jerome I RotterInstitute for Translational Genomics and Population Sciences and Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA,90502, USA.
Shehzad SaeedDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Ellen J ScherlDepartment of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
Mark S SilverbergDepartments of Medicine, Surgery, Public Health Sciences, Immunology, and Molecular and Medical Genetics, University of Toronto, Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Toronto General Hospital Research Institute, Toronto, Ontario M5S 2J7, Canada.
Ann SilvermanDepartment of Gastroenterology, Henry Ford Health System Detroit, MI 48208, USA.
Stephan R TarganF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
John F ValentineDivision of Gastroenterology, Hepatology and Nutrition, University of Utah, Salt Lake City, Utah.
Ming-Hsi WangMeyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Claire L SimpsonStatistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA.
S Louis BridgesDivision of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Robert P KimberlyDivision of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Judy H ChoDepartment of Medicine and Genetics, Yale University, New Haven, CT 06520, USA.
Anna Di RienzoCommittee on Clinical Pharmacology and Pharmacogenomics, and the Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.
Linda W H KaoDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA.
Dermot P B McGovern *F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90049, USA.
Steven R Brant *Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21231, USA.
Subra Kugathasan *Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory University · USJohns Hopkins University · USCedars-Sinai Medical Center · USUniversity of Alabama at Birmingham · USUniversity of Chicago · USChildren's Hospital of Philadelphia · USThe Lundquist Institute · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USBaylor College of Medicine · USCase Western Reserve University · USCincinnati Children's Hospital Medical Center · USComer Children's Hospital · USCook Children's Medical Center · USCornell University · USHenry Ford Health System · USLouisiana State University Health Sciences Center Shreveport · USMichael E. DeBakey VA Medical Center · USMonroe Carell Jr. Children's Hospital · USMontreal Heart Institute · CA

Funding

Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI TARGAN, STEPHAN R. · 1992 to 2020
$31.1M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
Inflammatory Bowel Disease Genetics Consortium Data Coordinating CenterU01DK062429 · NIDDK · YALE UNIVERSITY · PI CHO, JUDY H. · 2002 to 2016
$16.8M
Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBDU24DK062429 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ling-shiang Chuang, Ron Do · 2017 to 2026
$13.9M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
Utilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2M
The Role of HLA and KIR in Rheumatoid Arthritis and Crohn's DiseaseU01AI067068 · NIAID · STANFORD UNIVERSITY · PI ERLICH, HENRY A, TRACHTENBERG, ELIZABETH A · 2005 to 2014
$10.9M
Yale University Inflammatory Bowel Disease Genetics Research CenterU01DK062422 · NIDDK · YALE UNIVERSITY · PI Ling-shiang Chuang · 2002 to 2026
$10.8M
IBD Gene Mapping by Clinical and Population SubsetsU01DK062431 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Steven R Brant · 2002 to 2026
$10.7M
AHRQ HHS HS021747AHRQ HHS R01 HS021747NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001417NCRR NIH HHS M01 RR000032NCRR NIH HHS M01-RR-00032NHLBI NIH HHS HL06957NIAID NIH HHS AI067068NIAID NIH HHS U01 AI067068NIAMS NIH HHS AR-62278NIAMS NIH HHS N01 AR002247NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P01 AR49084NIDCR NIH HHS U54 DE023789NIDCR NIH HHS U54DE023789-01NIDDK NIH HHS DK046763-19NIDDK NIH HHS DK062413NIDDK NIH HHS DK062420NIDDK NIH HHS DK062422NIDDK NIH HHS DK062423NIDDK NIH HHS DK062429NIDDK NIH HHS DK062431NIDDK NIH HHS DK062432NIDDK NIH HHS DK087694NIDDK NIH HHS P01 DK046763NIDDK NIH HHS R01 DK087694NIDDK NIH HHS U01 DK062413NIDDK NIH HHS U01 DK062418NIDDK NIH HHS U01 DK062420NIDDK NIH HHS U01 DK062422NIDDK NIH HHS U01 DK062423NIDDK NIH HHS U01 DK062429NIDDK NIH HHS U01 DK062431NIDDK NIH HHS U01 DK062432NIDDK NIH HHS U24 DK062429
6 · The paper itself

Abstract

BACKGROUND &

aimsInflammatory bowel disease (IBD) has familial aggregation in African Americans (AAs), but little is known about the molecular genetic susceptibility. Mapping studies using the Immunochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but the contribution of the 163 loci and European admixture to IBD risk in AAs is unclear. We performed a genetic mapping study using the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AAs and identify new associated loci.

methodsWe recruited AAs with IBD and without IBD (controls) from 34 IBD centers in the United States; additional controls were collected from 4 other Immunochip studies. Association and admixture loci were mapped for 1088 patients with Crohn's disease, 361 with ulcerative colitis, 62 with IBD type unknown, and 1797 controls; 130,241 autosomal single-nucleotide polymorphisms (SNPs) were analyzed.

resultsThe strongest associations were observed between ulcerative colitis and HLA rs9271366 (P = 7.5 × 10(-6)), Crohn's disease and 5p13.1 rs4286721 (P = 3.5 × 10(-6)), and IBD and KAT2A rs730086 (P = 2.3 × 10(-6)). Additional suggestive associations (P < 4.2 × 10(-5)) were observed between Crohn's disease and IBD and African-specific SNPs in STAT5A and STAT3; between IBD and SNPs in IL23R, IL12B, and C2orf43; and between ulcerative colitis and SNPs near HDAC11 and near LINC00994. The latter 3 loci have not been previously associated with IBD, but require replication. Established Caucasian associations were replicated in AAs (P < 3.1 × 10(-4)) at NOD2, IL23R, 5p15.3, and IKZF3. Significant admixture (P < 3.9 × 10(-4)) was observed for 17q12-17q21.31 (IZKF3 through STAT3), 10q11.23-10q21.2, 15q22.2-15q23, and 16p12.2-16p12.1. Network analyses showed significant enrichment (false discovery rate <1 × 10(-5)) in genes that encode members of the JAK-STAT, cytokine, and chemokine signaling pathways, as well those involved in pathogenesis of measles.

conclusionsIn a genetic analysis of 3308 AA IBD cases and controls, we found that many variants associated with IBD in Caucasians also showed association evidence with these diseases in AAs; we also found evidence for variants and loci not previously associated with IBD. The complex genetic factors that determine risk for or protection against IBD in different populations require further study.

Indexed as

Polymorphism, Single NucleotideAdultAgedBlack or African AmericanColitis, UlcerativeCrohn DiseaseFemaleGenetic LociGenetic Predisposition to DiseaseHumansInflammatory Bowel DiseasesMaleMiddle AgedRisk FactorsUnited StatesWhite PeopleEthnicityGenetic VariantIntestinal InflammationRace

Identifiers

PMID26278503
PMCPMC4685036
OpenAlexW1938958129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.