Evidence map›Paper›PMID 26278492›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2016

Skin tissue repair: Matrix microenvironmental influences.

Alan Wells, Austin Nuschke, Cecelia C Yates

Abstract readReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alan WellsDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA. Electronic address: wellsa@upmc.edu.
Austin NuschkeDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.
Cecelia C YatesDepartment of Health Development and Promotion, University of Pittsburgh, Pittsburgh, PA 15213 USA; McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213 USA.

Funding

Spatial Segregation of Cell Functioning During MotilityR01GM069668 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WELLS, ALAN · 2004 to 2019
$4.7M
Dermal-Epidermal Communication during Wound HealingR01GM063569 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WELLS, ALAN · 2003 to 2018
$3.7M
Training Program in Skin Biology and CancerT32CA175294 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIRKWOOD, JOHN MUNN · 2014 to 2018
$973k
Dermal-Epidermal Communication during Wound HealingR56GM063569 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WELLS, ALAN · 2008 to 2008
$341k
NCI NIH HHS T32 CA175294NCI NIH HHS T32CA175294NIGMS NIH HHS GM63569NIGMS NIH HHS GM69668NIGMS NIH HHS R01 GM063569NIGMS NIH HHS R01 GM069668NIGMS NIH HHS R56 GM063569
6 · The paper itself

Abstract

The process of repair of wounded skin involves intricate orchestration not only between the epidermal and dermal compartments but also between the resident and immigrant cells and the local microenvironment. Only now are we beginning to appreciate the complex roles played by the matrix in directing the outcome of the repair processes, and how this impacts the signals from the various cells. Recent findings speak of dynamic and reciprocal interactions that occurs among the matrix, growth factors, and cells that underlies this integrated process. Further confounding this integration are the physiologic and pathologic situations that directly alter the matrix to impart at least part of the dysrepair that occurs. These topics will be discussed with a call for innovative model systems of direct relevance to the human situation.

Indexed as

Wound HealingAnimalsCellular MicroenvironmentDisease Models, AnimalExtracellular MatrixHumansIntercellular Signaling Peptides and ProteinsSkinIntercellular Signaling Peptides and ProteinsChronic woundCollagenDecorinExtracellular matrixMatrikine signalingSkin organ culturesTenascin-CWound healing

Identifiers

PMID26278492
PMCPMC4753148

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.