ArticleNature communications2015
Sperm navigation along helical paths in 3D chemoattractant landscapes.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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Who cites it
78 citing papers in PubMed.
- Precise 3D Tracking of Highly Non-Planar Eukaryotic Flagellar Beating Patterns Using Digital Holographic Microscopy.Small methods · 2026Article
- Chirality Transfer via Orientational Order of Micellar Assemblies on Gold Nanocrystals.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Refined trajectory smoothing and deep learning classification of human sperm motility.Human reproduction (Oxford, England) · 2026Article
- Light-Dependent Switching of Circling Handedness in Microswimmer Navigation.Physical review letters · 2026Article
- Perspective on Interdisciplinary Approaches on Chemotaxis.Angewandte Chemie (International ed. in English) · 2025Review
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives.Folia microbiologica · 2025Review
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Magnetic control of soft microrobots near step-out frequency: Characterization and analysis.Computational and structural biotechnology journal · 2024Article
- Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes.FASEB bioAdvances · 2024Review
- Reinforcement learning of biomimetic navigation: a model problem for sperm chemotaxis.The European physical journal. E, Soft matter · 2024Article
- Digital in-line holographic microscopy for label-free identification and tracking of biological cells.Military Medical Research · 2024Review
- Fluid flow reconstruction around a free-swimming sperm in 3D.bioRxiv : the preprint server for biology · 2024Article
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- Light, Matter, Action: Shining Light on Active Matter.ACS photonics · 2023Review
- Multi-Illumination Single-Holographic-Exposure Lensless Fresnel (MISHELF) Microscopy: Principles and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- cAMP and the Fibrous Sheath Protein CABYR (CaInternational journal of molecular sciences · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm require a sense of direction to locate the egg for fertilization. They follow gradients of chemical and physical cues provided by the egg or the oviduct. However, the principles underlying three-dimensional (3D) navigation in chemical landscapes are unknown. Here using holographic microscopy and optochemical techniques, we track sea urchin sperm navigating in 3D chemoattractant gradients. Sperm sense gradients on two timescales, which produces two different steering responses. A periodic component, resulting from the helical swimming, gradually aligns the helix towards the gradient. When incremental path corrections fail and sperm get off course, a sharp turning manoeuvre puts sperm back on track. Turning results from an 'off' Ca(2+) response signifying a chemoattractant stimulation decrease and, thereby, a drop in cyclic GMP concentration and membrane voltage. These findings highlight the computational sophistication by which sperm sample gradients for deterministic klinotaxis. We provide a conceptual and technical framework for studying microswimmers in 3D chemical landscapes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.