ArticleRespirology (Carlton, Vic.)2015
Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.
Manuela Platé, Phillippa J Lawson, Michael R Hill, Richard P Marshall, Helen L Booth, Meena Kumari, Geoffrey J Laurent, John R Hurst, Rachel C Chambers
Open access · hybridAbstract readLetter
In one paragraphArticle in Respirology (Carlton, Vic.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 1 country.
Phillippa J LawsonCentre for Inflammation and Tissue Repair, University College London, London, UK.
Michael R HillCentre for Inflammation and Tissue Repair, University College London, London, UK.
Richard P MarshallCentre for Inflammation and Tissue Repair, University College London, London, UK.
Helen L BoothDepartment of Thoracic Medicine, University College Hospital, London, UK.
Meena KumariFaculty of Population Health Sciences, University College London, London, UK.
Geoffrey J LaurentCentre for Inflammation and Tissue Repair, University College London, London, UK.
John R HurstCentre for Inflammation and Tissue Repair, University College London, London, UK.
Rachel C ChambersCentre for Inflammation and Tissue Repair, University College London, London, UK.
Centre for Inflammation Research · GBUniversity College Hospital · GBUniversity College London · GB
Funding
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2MCHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYSR37AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G · 1999 to 2008
$4.3MSocio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5MSocioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1MAging pathways polymorphisms in older personsR01AG024233 · NIA · UNIVERSITY OF CAMBRIDGE · PI MELZER, DAVID · 2004 to 2007
$1.2MSOCIAL FACTORS INFLUENCING MEDICAL OUTCOME MEASURESR01HS006516 · AHRQ · UNIVERSITY OF LONDON · PI MARMOT, MICHAEL G · 1990 to 1995
–AHRQ HHS HS06516British Heart Foundation PG/03/029British Heart Foundation RG/02/005Medical Research Council MC_U137686855Medical Research Council MR/N01104X/1NHLBI NIH HHS HL36310NIA NIH HHS AG13196NIA NIH HHS R01AG1764406S1NIA NIH HHS R01AG24233Wellcome Trust 051154
6 · The paper itselfAbstract
Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene-environment interactions. Proteinase-activated receptor-1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case-control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis (P = 0.003, OR = 0.68 (0.52-0.88)).
Indexed as
AdultAllelesCase-Control StudiesFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticProtective FactorsReceptor, PAR-1SarcoidosisReceptor, PAR-1F2R promoterproteinase-activated receptor-1sarcoidosissingle nucleotide polymorphism
Identifiers
PMID26278396
PMCPMC4737093
OpenAlexW1648130725
What OpenQuestion holds
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LicenceCC BY
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