ArticleScientific reports2015
Examining the role of different age groups, and of vaccination during the 2012 Minnesota pertussis outbreak.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Homophily within and across groups.Nature communications · 2025Article
- Factors Associated with More Severe Disease in Infants and Children with Pertussis in the Post-Pandemic Era: A Single-Center Retrospective Study.Pathogens (Basel, Switzerland) · 2025Article
- Sorting out assortativity: When can we assess the contributions of different population groups to epidemic transmission?PloS one · 2024Article
- Article
- Spatio-temporal comparison of pertussis outbreaks in Olmsted County, Minnesota, 2004-2005 and 2012: a population-based study.BMJ open · 2019Article
- On the role of different age groups during pertussis epidemics in California, 2010 and 2014.Epidemiology and infection · 2019Article
- On the Role of Different Age Groups and Pertussis Vaccines During the 2012 Outbreak in Wisconsin.Open forum infectious diseases · 2018Article
- Article
- On the Relative Role of Different Age Groups During Epidemics Associated With Respiratory Syncytial Virus.The Journal of infectious diseases · 2018Article
- Population effect of influenza vaccination under co-circulation of non-vaccine variants and the case for a bivalent A/H3N2 vaccine component.Epidemics · 2017Article
- [Outbreak of Whooping cough in 2016.Écija, Seville, Spain].Revista espanola de salud publica · 2017Article
- Temporally Varying Relative Risks for Infectious Diseases: Implications for Infectious Disease Control.Epidemiology (Cambridge, Mass.) · 2017Review
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Authors and funding
5 authors.
Funding
Abstract
There is limited information on the roles of different age groups during pertussis outbreaks. Little is known about vaccine effectiveness against pertussis infection (both clinically apparent and subclinical), which is different from effectiveness against reportable pertussis disease, with the former influencing the impact of vaccination on pertussis transmission in the community. For the 2012 pertussis outbreak in Minnesota, we estimated odds ratios for case counts in pairs of population groups before vs. after the epidemic's peak. We found children aged 11-12y, 13-14y and 8-10y experienced the greatest rates of depletion of susceptible individuals during the outbreak's ascent, with all ORs for each of those age groups vs. groups outside this age range significantly above 1, with the highest ORs for ages 11-12y. Receipt of the fifth dose of DTaP was associated with a decreased relative role during the outbreak's ascent compared to non-receipt [OR 0.16 (0.01, 0.84) for children aged 5, 0.13 (0.003, 0.82) for ages 8-10y, indicating a protective effect of DTaP against pertussis infection. No analogous effect of Tdap was detected. Our results suggest that children aged 8-14y played a key role in propagating this outbreak. The impact of immunization with Tdap on pertussis infection requires further investigation.
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