Evidence map›Paper›PMID 26278050›Full record

ArticleCell metabolism2015

Palatability Can Drive Feeding Independent of AgRP Neurons.

Raphaël G P Denis, Aurélie Joly-Amado, Emily Webber, Fanny Langlet, Marie Schaeffer, Stéphanie L Padilla, Céline Cansell, Bénédicte Dehouck, Julien Castel, Anne-Sophie Delbès and 13 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Review
  2. Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026
    Review
  3. Article
  4. Review
  5. Article
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  8. Article
  9. Review
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  11. Article
  12. Neurocircuitry of Predatory Hunting.Neuroscience bulletin · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Raphaël G P DenisUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Aurélie Joly-AmadoUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Emily WebberDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1453, USA; National Institute of Drug Abuse, Baltimore, MD 21224, USA.
Fanny LangletInstitut national de la santé et de la recherche médicale, Jean-Pierre Aubert Research Center, U837, 59000 Lille, France; Faculté de Médecine, Université droit et santé de Lille, 59000 Lille, France.
Marie SchaefferCentre National la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut de Génomique Fonctionnelle, 34000 Montpellier, France; Institut national de la santé et de la recherche médicale, U661, 34000 Montpellier, France; Unité Mixte de Recherche 5203, University of Montpellier, 34000 Montpellier, France.
Stéphanie L PadillaHoward Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Céline CansellUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Bénédicte DehouckInstitut national de la santé et de la recherche médicale, Jean-Pierre Aubert Research Center, U837, 59000 Lille, France; Faculté de Médecine, Université droit et santé de Lille, 59000 Lille, France.
Julien CastelUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Anne-Sophie DelbèsUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Sarah MartinezUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Amélie LacombeUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Claude RouchUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Nadim KassisUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Jean-Alain FehrentzCentre National la Recherche Scientifique, Institut des Biomolécules Max Mousseron, Unité Mixte de Recherche 5247, Ecole Nationale Supérieure de Chimie de Montpellier, Université Montpellier, 34093 Montpellier Cedex 5, France.
Jean MartinezCentre National la Recherche Scientifique, Institut des Biomolécules Max Mousseron, Unité Mixte de Recherche 5247, Ecole Nationale Supérieure de Chimie de Montpellier, Université Montpellier, 34093 Montpellier Cedex 5, France.
Pascal VerdiéCentre National la Recherche Scientifique, Institut des Biomolécules Max Mousseron, Unité Mixte de Recherche 5247, Ecole Nationale Supérieure de Chimie de Montpellier, Université Montpellier, 34093 Montpellier Cedex 5, France.
Thomas S HnaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Richard D PalmiterHoward Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Michael J KrashesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1453, USA; National Institute of Drug Abuse, Baltimore, MD 21224, USA.
Ali D GülerHoward Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Department of Biology, University of Virginia, Charlottesville, VA 22904-4328, USA.
Christophe MagnanUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Serge LuquetUnité de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France. Electronic address: serge.luquet@univ-paris-diderot.fr.

Funding

Effect of Killing or Removing GABA from NPY/AgRP NeuronsR01DA024908 · NIDA · UNIVERSITY OF WASHINGTON · PI PALMITER, RICHARD D. · 2007 to 2021
$3.5M
Howard Hughes Medical InstituteNIDA NIH HHS R01 DA024908
6 · The paper itself

Abstract

Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake--a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.

Indexed as

Agouti-Related ProteinAnimalsDopamineEatingHypothalamusMiceMice, Inbred C57BLMice, KnockoutNeuronsSignal TransductionAgouti-Related ProteinDopamine

Identifiers

PMID26278050
PMCPMC5024566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.