Evidence map›Paper›PMID 26278027›Full record

ArticleBioorganic & medicinal chemistry2015

1,5-Disubstituted benzimidazoles that direct cardiomyocyte differentiation from mouse embryonic stem cells.

Karl J Okolotowicz, Paul Bushway, Marion Lanier, Cynthia Gilley, Mark Mercola, John R Cashman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. The Disappearing Director: The Case of DirectedAdvanced synthesis & catalysis · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karl J OkolotowiczHuman BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA. Electronic address: kokolotowicz@hbri.org.
Paul BushwaySanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0695, La Jolla, CA 92093-0695, USA.
Marion LanierHuman BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.
Cynthia GilleyHuman BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.
Mark MercolaSanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0695, La Jolla, CA 92093-0695, USA.
John R CashmanHuman BioMolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.
Human BioMolecular Research Institute · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
microRNAs and Integrative Control on Cardiopoiesis - CHANGE OF GRANTEE INSTITUTIOR01HL113601 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MERCOLA, MARK · 2012 to 2016
$2.2M
Myocardial Angiogenesis and CardioprotectionR01HL108176 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MERCOLA, MARK · 2012 to 2015
$1.9M
Molecular Biology of Heart InductionR37HL059502 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MERCOLA, MARK · 2007 to 2011
$1.6M
NCI NIH HHS P30 CA030199NHLBI NIH HHS R01 HL108176NHLBI NIH HHS R01HL108176NHLBI NIH HHS R01 HL113601NHLBI NIH HHS R37 HL059502NHLBI NIH HHS R37HL059502
6 · The paper itself

Abstract

Cardiomyopathy is the leading cause of death worldwide. Despite progress in medical treatments, heart transplantation is one of the only current options for those with infarcted heart muscle. Stem cell differentiation technology may afford cell-based therapeutics that may lead to the generation of new, healthy heart muscle cells from undifferentiated stem cells. Our approach is to use small molecules to stimulate stem cell differentiation. Herein, we describe a novel class of 1,5-disubstituted benzimidazoles that induce differentiation of stem cells into cardiac cells. We report on the evaluation in vitro for cardiomyocyte differentiation and describe structure-activity relationship results that led to molecules with drug-like properties. The results of this study show the promise of small molecules to direct stem cell lineage commitment, to probe signaling pathways and to develop compounds for the stimulation of stem cells to repair damaged heart tissue.

Indexed as

AnimalsBenzimidazolesCell DifferentiationCells, CulturedMiceMouse Embryonic Stem CellsMyocytes, CardiacStructure-Activity RelationshipBenzimidazolesBenzimidazolesCardiomyocytesCardiomyogenesisEmbryonic stem cellsHigh content screen

Identifiers

PMID26278027
PMCPMC4766108
OpenAlexW1196609684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.