Evidence map›Paper›PMID 26277900›Full record

ArticleCellular & molecular immunology2017

Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy.

Jianhong Zhang, Caroline E Dunk, Melissa Kwan, Rebecca L Jones, Lynda K Harris, Sarah Keating, Stephen J Lye

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
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  4. The Placenta as an Immunological Environment.British journal of biomedical science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jianhong ZhangResearch Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.
Caroline E DunkResearch Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.
Melissa KwanResearch Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.
Rebecca L JonesInstitute of Human Development, University of Manchester, Manchester, M13 9WL, UK.
Lynda K HarrisInstitute of Human Development, University of Manchester, Manchester, M13 9WL, UK.
Sarah KeatingDepartment of Pathology, University of Toronto, Toronto, ON M5G 1L4, Canada.
Stephen J LyeResearch Centre for Women's and Infants' Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada.
Mount Sinai Hospital · CAUniversity of Manchester · GBLunenfeld-Tanenbaum Research Institute · CAUniversity of Toronto · CA

Funding

Medical Research Council MR/N010892/1
6 · The paper itself

Abstract

Decidual natural killer (dNK) cells express an array of activation receptors to regulate placental immunity and development during early pregnancy. We investigated the functional character of human dNK cells during the first and second trimester of gestation and the interaction between dNK and trophoblast cells. Although the frequency of CD56

Indexed as

Cell CommunicationDeciduaFemaleHumansInterleukin-8Killer Cells, NaturalLectins, C-TypeLymphocyte CountNeovascularization, PhysiologicNK Cell Lectin-Like Receptor Subfamily KPhenotypePregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondReceptors, Natural Killer CellTrophoblastsInterleukin-8KLRF1 protein, humanKLRK1 protein, humanLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily KReceptors, Natural Killer CellVascular Endothelial Growth Factor A

Identifiers

PMID26277900
PMCPMC5301153
OpenAlexW2343948691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.