ArticleJournal of epidemiology2015
Heart Rate Variability, Insulin Resistance, and Insulin Sensitivity in Japanese Adults: The Toon Health Study.
Article in Journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Exploring heart rate variability in polycystic ovary syndrome: implications for cardiovascular health: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Omega and heart rate variability in overweight and obese schoolchildren.Pediatric research · 2025Trial
- α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study.Cardiovascular diabetology · 2017Trial
- Rosiglitazone influences adipose tissue distribution without deleterious impact on heart rate variability in coronary heart disease patients with type 2 diabetes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Trial
- Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity.International journal of obesity (2005) · 2026Article
- A Wearable-Derived Autonomic Component Is Associated with Cardiovascular Health in Community-Dwelling Adults: A Cross-Sectional Analysis from the Longevity Check-Up 8+ Study.Medical sciences (Basel, Switzerland) · 2026Article
- Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities.Journal of diabetes and metabolic disorders · 2026Review
- Article
- Association between time-domain heart rate variability, diastolic dysfunction and unplanned readmission to cardiovascular department in older type 2 diabetes mellitus patients.BMC geriatrics · 2026Article
- Pulse Rate Variability and All-Cause Mortality Risk in the General Japanese Population.Circulation reports · 2026Article
- Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity.Scientific reports · 2025Article
- Association between visceral fat area and heart rate variability in high altitude migrants with OSA: the mediating effect of insulin resistance.Lipids in health and disease · 2025Article
- Heart rate variability in cardiovascular disease diagnosis, prognosis and management.Frontiers in cardiovascular medicine · 2025Review
- Genetic markers of cardiac autonomic neuropathy in the Kazakh population.BMC cardiovascular disorders · 2024Article
- Longitudinal Changes in Arterial Stiffness Associated with Physical Activity Intensity: The Toon Health Study.Journal of atherosclerosis and thrombosis · 2024Article
- The relationship between heart rate variability and glucose clearance in healthy men and women.PloS one · 2024Article
- Combining Celiac and Hepatic Vagus Nerve Neuromodulation Reverses Glucose Intolerance and Improves Glycemic Control in Pre- and Overt-Type 2 Diabetes Mellitus.Biomedicines · 2023Article
- In Type 2 Diabetes Mellitus, normalization of hemoglobin A1c accompanies reduced sensitivity to pressure at the sternum.Frontiers in neuroscience · 2023Article
- The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study.Diabetes care · 2022Article
- Factors Associated with Reduced Heart Rate Variability in the General Japanese Population: The Iwaki Cross-Sectional Research Study.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough impaired cardiac autonomic function is associated with an increased risk of type 2 diabetes in Caucasians, evidence in Asian populations with a lower body mass index is limited.
methodsBetween 2009-2012, the Toon Health Study recruited 1899 individuals aged 30-79 years who were not taking medication for diabetes. A 75-g oral glucose tolerance test was used to diagnose type 2 diabetes, and fasting and 2-h-postload glucose and insulin concentrations were measured. We assessed the homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt's insulin sensitivity index (ISI). Pulse was recorded for 5 min, and time-domain heart rate variability (HRV) indices were calculated: the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive difference (RMSSD). Power spectral analysis provided frequency domain measures of HRV: high frequency (HF) power, low frequency (LF) power, and the LF:HF ratio.
resultsMultivariate-adjusted logistic regression models showed decreased SDNN, RMSSD, and HF, and increased LF:HF ratio were associated significantly with increased HOMA-IR and decreased ISI. When stratified by overweight status, the association of RMSSD, HF, and LF:HF ratio with decreased ISI was also apparent in non-overweight individuals. The interaction between LF:HF ratio and decreased ISI in overweight individuals was significant, with the odds ratio for decreased ISI in the highest quartile of LF:HF ratio in non-overweight individuals being 2.09 (95% confidence interval, 1.41-3.10).
conclusionsReduced HRV was associated with insulin resistance and lower insulin sensitivity. Decreased ISI was linked with parasympathetic dysfunction, primarily in non-overweight individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.