Evidence map›Paper›PMID 26277871›Full record

ArticleScientific reports2015

Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis.

Guo-Zhong Tao, Bo Liu, Rong Zhang, Gigi Liu, Fizan Abdullah, Mary Cay Harris, Mary L Brandt, Richard A Ehrenkranz, Corinna Bowers, Camilia R Martin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Review
  6. Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis.Gastroenterology research and practice · 2019
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Guo-Zhong TaoDepartment of Surgery, Stanford University School of Medicine, Stanford, USA.
Bo LiuDepartment of Surgery, Stanford University School of Medicine, Stanford, USA.
Rong ZhangDepartment of Surgery, Stanford University School of Medicine, Stanford, USA.
Gigi Liu1] Department of Surgery, Stanford University School of Medicine, Stanford, USA [2] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Fizan Abdullah1] Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, USA [2].
Mary Cay HarrisDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, USA.
Mary L BrandtDepartment of Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, USA.
Richard A EhrenkranzDepartment of Pediatrics, Yale University School of Medicine, New Haven, USA.
Corinna Bowers1] Division of Pediatric Surgery, Nationwide Children's Hospital, Columbus, USA [2] Department of Surgery, Ohio State College of Medicine, Columbus, USA.
Camilia R MartinDepartment of Neonatology, Beth Israel Deaconess Medical Center, Boston, USA.
R Lawrence Moss1] Division of Pediatric Surgery, Nationwide Children's Hospital, Columbus, USA [2] Department of Surgery, Ohio State College of Medicine, Columbus, USA.
Karl G Sylvester1] Department of Surgery, Stanford University School of Medicine, Stanford, USA [2] Lucile Packard Children's Hospital Stanford, Stanford, USA [3] Center for Fetal and Maternal Health, Stanford Children's Health, Stanford, USA.
Stanford University · USNationwide Children's Hospital · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USChildren's Hospital of Philadelphia · USJohns Hopkins University · USLucile Packard Children's Hospital · USYale University · US

Funding

FDA HHS U01 FD004194
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal (GI) medical/surgical emergency of the newborn and a leading cause of preterm neonate morbidity and mortality. NEC is a challenge to diagnose since it often shares similar clinical features with neonatal sepsis. In the present study, plasma protein profiling was compared among NEC, sepsis and control cohorts using gel electrophoresis, immunoblot and mass spectrometry. We observed significant impairment in the formation of fibrinogen-γ dimers (FGG-dimer) in the plasma of newborns with NEC that could efficiently differentiate NEC and sepsis with a high level of sensitivity and specificity. Interestingly, the impaired FGG-dimer formation could be restored in NEC plasma by the addition of exogenous active factor XIII (FXIII). Enzymatic activity of FXIII was determined to be significantly lower in NEC subject plasma for crosslinking FGG when compared to sepsis. These findings demonstrate a potential novel biomarker and related biologic mechanism for diagnosing NEC, as well as suggest a possible therapeutic strategy.

Indexed as

Area Under CurveBiomarkersChromatography, High Pressure LiquidDimerizationElectrophoresis, Polyacrylamide GelEnterocolitis, NecrotizingFactor XIIIFemaleFibrinogenHumansInfantMalePremature BirthROC CurveSepsisTandem Mass SpectrometryBiomarkersFactor XIIIFibrinogen

Identifiers

PMID26277871
PMCPMC4642514
OpenAlexW2418784918

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.