ArticleJACC. Heart failure2015
Further Peripheral Vascular Dysfunction in Heart Failure Patients With a Continuous-Flow Left Ventricular Assist Device: The Role of Pulsatility.
Article in JACC. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04539093 (Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Endothelial Function in Patients With Advanced Heart Failure Requiring Mechanical Circulatory Support
Who cites it
41 citing papers in PubMed, 96 citations in OpenAlex.
- From Continuous-Flow Mechanical Circulatory Support to Heart Transplantation: Hemodynamic, Immunometabolic, and Body Composition Determinants of Rehabilitation Outcomes.Journal of clinical medicine · 2026Review
- A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.Biomechanics and modeling in mechanobiology · 2026Article
- Vascular function in patients with advanced heart failure and continuous-flow or pulsatile ventricular assist devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Physiologic effects of different hemodynamic patterns of LVAD.Frontiers in cardiovascular medicine · 2025Review
- Predictors and Impact of Prolonged Vasoplegia After Continuous-Flow Left Ventricular Assist Device Implantation.JACC. Advances · 2024Article
- Hemodynamic Evaluation of Asynchronous Speed Modulation of a Continuous-Flow Left Ventricular Assist Device in an Acute-Myocardial Injury Sheep Model.Annals of biomedical engineering · 2024Article
- Review
- Pulsatility and flow patterns across macro- and microcirculatory arteries of continuous-flow left ventricular assist device patients.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Neurologic Complications in Patients With Left Ventricular Assist Devices.The Canadian journal of cardiology · 2023Review
- Pulsatility hemodynamics during speed modulation of continuous-flow total artificial heart in a chronic in vivo model.Artificial organs · 2022Article
- Does cardiac recovery favorably impact adverse events and outcomes of LVAD patients?The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement.Journal of clinical medicine · 2022Review
- Contrast Ultrasound Assessment of Skeletal Muscle Recruitable Perfusion after Permanent Left Ventricular Assist Device Implantation: Implications for Functional Recovery.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Cerebral Microvascular Injury in Patients with Left Ventricular Assist Device: a Neuropathological Study.Translational stroke research · 2022Article
- Impact of angiotensin receptor-neprilysin inhibition on vascular function in heart failure with reduced ejection fraction: A pilot study.Physiological reports · 2022Article
- From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Review
- Physiologic Data-Driven Iterative Learning Control for Left Ventricular Assist Devices.Frontiers in cardiovascular medicine · 2022Article
- Assessment of ocular blood flow in continuous-flow ventricular assist device by laser speckle flowgraphy.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- Contrast-Enhanced Ultrasound of Muscle Perfusion May Indicate Patient Response to Left Ventricular Assist Device Therapy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Article
- Increased pulsatility index is associated with adverse outcomes in left ventricular assist device recipients.ESC heart failure · 2021Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesUsing flow-mediated vasodilation (FMD) and reactive hyperemia (RH), this study aimed to provide greater insight into left ventricular assist device (LVAD)-induced changes in peripheral vascular function.
backgroundPeripheral endothelial function is recognized to be impaired in patients with heart failure with reduced ejection fraction (HFrEF), but the peripheral vascular effects of continuous-flow LVAD implantation, now used as either a bridge to transplantation or as a destination therapy, remain unclear.
methodsSixty-eight subjects (13 New York Heart Association [NYHA] functional class II HFrEF patients, 19 NYHA functional class III/IV HFrEF patients, 20 NYHA functional class III/IV HFrEF patients post-LVAD implantation, and 16 healthy age-matched control subjects) underwent FMD and RH testing in the brachial artery with blood flow velocity, artery diameters, and pulsatility index (PI) assessed by ultrasound Doppler.
resultsPI was significantly lower in the LVAD group (2.0 ± 0.4) compared with both the HFrEF II (8.6 ± 0.8) and HFrEF III/IV (8.1 ± 0.9) patients, who, in turn, had significantly lower PI than the control subjects (12.8 ± 0.9). Likewise, LVAD %FMD/shear rate (0.09 ± 0.01 %Δ/s(-1)) was significantly reduced compared with all other groups (control subjects, 0.24 ± 0.03; HFrEF II, 0.17 ± 0.02; and HFrEF III/IV, 0.13 ± 0.02 %Δ/s(-1)), and %FMD/shear rate significantly correlated with PI (r = 0.45). RH was unremarkable across groups.
conclusionsAlthough central hemodynamics are improved in patients with HFrEF by a continuous-flow LVAD, peripheral vascular function is further compromised, which is likely due, at least in part, to the reduction in pulsatility that is a characteristic of such a mechanical assist device.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.