ArticleThe Journal of allergy and clinical immunology2016
Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Welding Fumes, a Risk Factor for Lung Diseases.International journal of environmental research and public health · 2020Pooled it
- Review
- Welding fume exposure and respiratory innate immune activation: metal-rich particles, inflammatory biomarkers, and immune-informed occupational prevention.Frontiers in immunology · 2026Review
- ThirdEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Occupationally Relevant Zinc- and Copper-Containing Metal Fumes Inhibit Human THP-1 Macrophage TNF and IL-6 Responses to Bacterial Stimuli.Global challenges (Hoboken, NJ) · 2025Article
- Oxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.Nature communications · 2024Article
- Vaccinating Welders against Pneumococcus: Evidence from a Systematic Review and Meta-Analysis.Vaccines · 2023Review
- Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission.American journal of respiratory and critical care medicine · 2022Review
- Cumulative occupational exposure to inorganic dust and fumes and invasive pneumococcal disease with pneumonia.International archives of occupational and environmental health · 2022Article
- Underground railway particulate matter and susceptibility to pneumococcal infection.EBioMedicine · 2022Article
- Article
- Lung toxicity profile of inhaled copper-nickel welding fume in A/J mice.Inhalation toxicology · 2022Article
- Air pollution and children's health: where next?BMJ paediatrics open · 2021Article
- The Impact of Nanoparticles on Innate Immune Activation by Live Bacteria.International journal of molecular sciences · 2020Review
- Influences of Nanoparticles Characteristics on the Cellular Responses: The Example of Iron Oxide and Macrophages.Nanomaterials (Basel, Switzerland) · 2020Article
- Occupational exposure to dust and to fumes, work as a welder and invasive pneumococcal disease risk.Occupational and environmental medicine · 2020Article
- Pneumococcal vaccination for welders: Global deployment within a multi-national corporation.American journal of industrial medicine · 2019Article
- Inhalation of iron-abundant gas metal arc welding-mild steel fume promotes lung tumors in mice.Toxicology · 2018Article
- E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.The European respiratory journal · 2018Article
- A cost-effective technique for generating preservable biomass smoke extract and measuring its effect on cell receptor expression in human bronchial epithelial cells.Biology methods & protocols · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundWelders are at increased risk of pneumococcal pneumonia. The mechanism for this association is not known. The capacity of pneumococci to adhere to and infect lower airway cells is mediated by host-expressed platelet-activating factor receptor (PAFR).
objectiveWe sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model.
methodsThe oxidative potential of MS-WF was assessed by their capacity to reduce antioxidants in vitro. Pneumococcal adhesion and infection of A549, BEAS-2B, and primary human bronchial airway cells were assessed by means of quantitative bacterial culture and expressed as colony-forming units (CFU). After intranasal instillation of MS-WF, mice were infected with Streptococcus pneumoniae, and bronchoalveolar lavage fluid (BALF) and lung CFU values were determined. PAFR protein levels were assessed by using immunofluorescence and immunohistochemistry, and PAFR mRNA expression was assessed by using quantitative PCR. PAFR was blocked by CV-3988, and oxidative stress was attenuated by N-acetylcysteine.
resultsMS-WF exhibited high oxidative potential. In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. Both CV-3988 and N-acetylcysteine reduced MS-WF-stimulated pneumococcal adhesion and infection of airway cells. MS-WF increased mouse lung PAFR mRNA expression and increased BALF and lung pneumococcal CFU values. In MS-WF-exposed mice CV-3988 reduced BALF CFU values.
conclusionsHypersusceptibility of welders to pneumococcal pneumonia is in part mediated by the capacity of welding fumes to increase PAFR-dependent pneumococcal adhesion and infection of lower airway cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.