ArticleVirchows Archiv : an international journal of pathology2015
Tumor infiltration pattern into the surrounding tissue has prognostic significance in advanced gastric cancer.
Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- Characteristics and prognosis of skip lymph node metastasis in gastric cancer: a retrospective study.World journal of surgical oncology · 2025Article
- Extracellular volume fraction determined by equilibrium contrast-enhanced computed tomography: correlation with histopathological findings in gastric cancer.Japanese journal of radiology · 2023Article
- Nomogram Based on Preoperative Fibrinogen and Systemic Immune-Inflammation Index Predicting Recurrence and Prognosis of Patients with Borrmann Type III Advanced Gastric Cancer.Journal of inflammation research · 2023Article
- Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer.World journal of gastrointestinal oncology · 2022Article
- Analysis of immune status in gastric adenocarcinoma with different infiltrating patterns and origin sites.Frontiers in immunology · 2022Article
- Human telomerase reverse transcriptase protein expression is associated with survival in patients with oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2022Article
- Risk factors for lymph node metastasis in cutaneous squamous cell carcinoma: a long-term retrospective study of Japanese patients.International journal of clinical oncology · 2021Article
- Prognostic significance of serum inflammation indexes in different Lauren classification of gastric cancer.Cancer medicine · 2021Article
- Baseline lesion number as an efficacy predictive and independent prognostic factor and its joint utility with TMB for PD-1 inhibitor treatment in advanced gastric cancer.Therapeutic advances in medical oncology · 2021Article
- Pathological tumor infiltrative pattern and sites of initial recurrence in stage II/III gastric cancer: Propensity score matching analysis of a multi-institutional dataset.Cancer medicine · 2018Article
- Clinical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer.In vivo (Athens, Greece)Article
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8 authors at 1 institution in 1 country.
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Abstract
Gastric cancer can be classified into three subgroups according to pattern of tumor infiltration into the surrounding tissue: INFa (expanding growth and a distinct border with the surrounding tissue), INFc (infiltrating growth and an indistinct border with the surrounding tissue), and INFb (in-between a and c). How the tumor infiltration pattern (INF) relates to prognosis and type of recurrence in advanced gastric cancer has not been sufficiently explored. We examined 805 consecutive advanced gastric adenocarcinoma patients who underwent curative gastrectomy at our institution between 1980 and 2005. Poor differentiation, serosal invasion, and lymph node metastasis were significantly more frequent in patients with INFc tumors than in those with INFa/b tumors. For patients with a T2 or T3 tumor, there was no significant difference in prognosis between those with INFa/b and with INFc. However, for patients with a T4a or T4b tumor, the prognosis of those with INFc was significantly worse than that of those with INFa/b. In multivariate analysis, INF was an independent prognostic indicator in T4a but not T2, T3, and T4b. Furthermore, the prognosis of T4 patients with INFc tumors was significantly worse than that of those with INFa/b, especially in node-negative but not in node-positive cases. In patients with a T4a or T4b tumor, peritoneal recurrence was significantly more frequent for those with INFc than for those with INFa/b. Our data indicate that INF is useful to predict the prognosis and recurrence pattern in T4a node-negative gastric cancer.
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