ArticleDrug and alcohol dependence2015
Does laboratory cue reactivity correlate with real-world craving and smoking responses to cues?
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analytic review of the effectiveness of mood inductions in eliciting emotion-based behavioral risk-taking and craving in the laboratory.Emotion (Washington, D.C.) · 2023Pooled it
- Do lab-based assessments of pretreatment smoking reinforcement and cue-specific craving predict smoking cessation with varenicline?Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Trial
- Appetitive startle modulation in the human laboratory predicts Cannabis craving in the natural environment.Psychopharmacology · 2018Trial
- Attentional Bias During a Novel Alcohol Cue Virtual Reality Paradigm.Alcohol, clinical & experimental research · 2026Article
- Reactivity to electronic nicotine delivery system (ENDS) cues in adults who smoke cigarettes and vape cannabis.Addictive behaviors · 2026Article
- Exploring the relationship between cue-induced craving and withdrawal craving in MUD individuals based on a virtual-reality cue exposure paradigm.BMC psychiatry · 2025Article
- Comparing the effectiveness of virtual reality vs 2D display-based cue reactivity paradigms to induce nicotine-craving: a behavioral and psychophysiological study.Scientific reports · 2025Article
- Distress tolerance and reactivity to negative affective cues in naturalistic environments of cannabis-using emerging adults.Drug and alcohol dependence · 2022Article
- A Person-Centered Analysis of Craving in Smoking-Cue-Exposure Research.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Momentary Influences on Self-Regulation in Two Populations With Health Risk Behaviors: Adults Who Smoke and Adults Who Are Overweight and Have Binge-Eating Disorder.Frontiers in digital health · 2022Article
- Are Machine Learning Methods the Future for Smoking Cessation Apps?Sensors (Basel, Switzerland) · 2021Article
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Interactive Effects of Naturalistic Drinking Context and Alcohol Sensitivity on Neural Alcohol Cue-Reactivity Responses.Alcoholism, clinical and experimental research · 2019Article
- Modeling subjective belief states in computational psychiatry: interoceptive inference as a candidate framework.Psychopharmacology · 2019Article
- [Effect of clinical characteristics on relapse of alcohol dependence: a prospective cohort study].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- The Attentional Bias in Current and Former Smokers.Frontiers in behavioral neuroscience · 2019Article
- Exacerbated Craving in the Presence of Stress and Drug Cues in Drug-Dependent Patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Observational
- Direct and Indirect Effects of Psychological Distress on Stress-Induced Smoking.Journal of studies on alcohol and drugs · 2017Article
- Beyond Cue Reactivity: Non-Drug-Related Motivationally Relevant Stimuli Are Necessary to Understand Reactivity to Drug-Related Cues.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Review
- A Bayesian Observer Model of Drug Craving.JAMA psychiatry · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundLaboratory cue reactivity (CR) assessments are used to assess smokers' responses to cues. Likewise, EMA recording is used to characterize real-world response to cues. Understanding the relationship between CR and EMA responses addresses the ecological validity of CR.
methodsIn 190 daily smokers not currently quitting, craving and smoking responses to cues were assessed in laboratory CR and by real-world EMA recording. Separate CR sessions involved 5 smoking-relevant cues (smoking, alcohol, negative affect, positive affect, smoking prohibitions), and a neutral cue. Subjects used EMA to monitor smoking situations for 3 weeks, completing parallel situational assessments (presence of others smoking, alcohol consumption, negative affect, positive affect, and smoking prohibitions, plus current craving) in smoking and non-smoking occasions (averaging 70 and 60 occasions each). Analyses correlated CR craving and smoking cue responses with EMA craving and smoking correlations with similar cues.
resultsAlthough some cues did not show main effects on average craving or smoking, a wide range of individual differences in response to cues was apparent in both CR and EMA data, providing the necessary context to assess their relationship. Laboratory CR measures of cue response were not correlated with real-world cue responses assessed by EMA. The average correlation was 0.03; none exceeded 0.32. One of 40 correlations examined was significantly greater than 0.
conclusionsLaboratory CR measures do not correlate with EMA-assessed craving or smoking in response to cues, suggesting that CR measures are not accurate predictors of how smokers react to relevant stimuli in the real world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.