ReviewMathematical biosciences2015
Modeling the hypothalamus-pituitary-adrenal axis: A review and extension.
Review in Mathematical biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- VeVaPy, a Python Platform for Efficient Verification and Validation of Systems Biology Models with Demonstrations Using Hypothalamic-Pituitary-Adrenal Axis Models.Entropy (Basel, Switzerland) · 2022Article
- Children and Adolescents Dietary Habits and Lifestyle Changes during COVID-19 Lockdown in Italy.Nutrients · 2022Article
- Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in medicine · 2022Article
- From work stress to disease: A computational model.PloS one · 2022Article
- Circadian rhythms and the HPA axis: A systems view.WIREs mechanisms of disease · 2021Review
- Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in medicine · 2021Article
- Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Frontiers in medicine · 2021Article
- A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks.Molecular systems biology · 2020Article
- Allostatic adaptation and personalized physiological trade-offs in the circadian regulation of the HPA axis: A mathematical modeling approach.Scientific reports · 2019Article
- Organ-On-A-ChipFrontiers in bioengineering and biotechnology · 2019Review
- Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder.Metabolic brain disease · 2018Article
- Perturbing the Hypothalamic-Pituitary-Adrenal Axis: A Mathematical Model for Interpreting PTSD Assessment Tests.Computational psychiatry (Cambridge, Mass.) · 2018Article
- Modeling and estimating the feedback mechanisms among depression, rumination, and stressors in adolescents.PloS one · 2018Article
- Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder.Psychological medicine · 2016Review
- A Dynamic Model of Post-Traumatic Stress Disorder for Military Personnel and Veterans.PloS one · 2016Article
- SD Meets OR: A New Synergy to Address Policy Problems.System dynamics reviewArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Multiple models of the hypothalamus-pituitary-adrenal (HPA) axis have been developed to characterize the oscillations seen in the hormone concentrations and to examine HPA axis dysfunction. We reviewed the existing models, then replicated and compared five of them by finding their correspondence to a dataset consisting of ACTH and cortisol concentrations of 17 healthy individuals. We found that existing models use different feedback mechanisms, vary in the level of details and complexities, and offer inconsistent conclusions. None of the models fit the validation dataset well. Therefore, we re-calibrated the best performing model using partial calibration and extended the model by adding individual fixed effects and an exogenous circadian function. Our estimated parameters reduced the mean absolute percent error significantly and offer a validated reference model that can be used in diverse applications. Our analysis suggests that the circadian and ultradian cycles are not created endogenously by the HPA axis feedbacks, which is consistent with the recent literature on the circadian clock and HPA axis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.