Evidence map›Paper›PMID 26276982›Full record

ArticleIEEE transactions on bio-medical engineering2016

Subspace Regularized Sparse Multitask Learning for Multiclass Neurodegenerative Disease Identification.

Xiaofeng Zhu, Heung-Il Suk, Seong-Whan Lee, Dinggang Shen

Abstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  4. IRMA: Machine learning-based harmonization ofEuropean journal of nuclear medicine and molecular imaging · 2025
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  14. A novel image signature-based radiomics method to achieve precise diagnosis and prognostic stratification of gliomas.Laboratory investigation; a journal of technical methods and pathology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaofeng Zhu
Heung-Il Suk
Seong-Whan Lee
Dinggang Shen

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Infant Brain Measurement and Super-Resolution Atlas ConstructionR01MH100217 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2013 to 2016
$2.3M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Fast, Robust Analysis of Large Population DataR01EB009634 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEN, DINGGANG · 2011 to 2014
$1.3M
NIA NIH HHS AG041721NIA NIH HHS AG042599NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIBIB NIH HHS EB006733NIBIB NIH HHS EB008374NIBIB NIH HHS EB009634NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB009634NIMH NIH HHS MH100217NIMH NIH HHS R01 MH100217
6 · The paper itself

Abstract

The high feature-dimension and low sample-size problem is one of the major challenges in the study of computer-aided Alzheimer's disease (AD) diagnosis. To circumvent this problem, feature selection and subspace learning have been playing core roles in the literature. Generally, feature selection methods are preferable in clinical applications due to their ease for interpretation, but subspace learning methods can usually achieve more promising results. In this paper, we combine two different methodological approaches to discriminative feature selection in a unified framework. Specifically, we utilize two subspace learning methods, namely, linear discriminant analysis and locality preserving projection, which have proven their effectiveness in a variety of fields, to select class-discriminative and noise-resistant features. Unlike previous methods in neuroimaging studies that mostly focused on a binary classification, the proposed feature selection method is further applicable for multiclass classification in AD diagnosis. Extensive experiments on the Alzheimer's disease neuroimaging initiative dataset showed the effectiveness of the proposed method over other state-of-the-art methods.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseArtificial IntelligenceBrainFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeuroimagingPositron-Emission Tomography

Identifiers

PMID26276982
PMCPMC4751062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.