ArticleJournal of immunology (Baltimore, Md. : 1950)2015
DNA Methylation Regulates the Differential Expression of CX3CR1 on Human IL-7Rαlow and IL-7Rαhigh Effector Memory CD8+ T Cells with Distinct Migratory Capacities to the Fractalkine.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- The epigenetic landscape of fate decisions in T cells.Nature immunology · 2025Review
- Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell.Immunological reviews · 2025Review
- Expression of IL-7RαPediatric gastroenterology, hepatology & nutrition · 2024Article
- Mucosal Immunity Related to CD8Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Aging gene signature of memory CD8Immunity & ageing : I & A · 2023Article
- Type-2 CD8Nature communications · 2023Article
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Review
- Implication of IL-7 receptor alpha chain expression by CD8Immunity & ageing : I & A · 2022Review
- Alterations in high-dimensional T-cell profile and gene signature of immune aging in HIV-infected older adults without viremia.Aging cell · 2022Article
- Evaluation of CX3CR1 gene DNA methylation in developmental dysplasia of the hip (DDH).Journal of orthopaedic surgery and research · 2022Article
- Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinoma.Oncoimmunology · 2022Article
- DNA Methylation and Immune Memory Response.Cells · 2021Review
- Epigenetic strategies to boost CAR T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Review
- Effector Memory CD8Pediatric gastroenterology, hepatology & nutrition · 2021Article
- PDTC ameliorates neuropathic pain by inhibiting microglial activation <em>via</em> blockage of the TNFα-CX3CR1 pathway.European journal of histochemistry : EJH · 2021Article
- Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.Science immunology · 2021Article
- CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis.PLoS pathogens · 2020Article
- IL-7 receptor alpha defines heterogeneity and signature of human effector memory CD8Cellular immunology · 2020Article
- Anti-Pituitary and Anti-Hypothalamus Autoantibody Associations with Inflammation and Persistent Hypogonadotropic Hypogonadism in Men with Traumatic Brain Injury.Journal of neurotrauma · 2020Observational
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
DNA methylation is an epigenetic mechanism that modulates gene expression in mammalian cells including T cells. Memory T cells are heterogeneous populations. Human effector memory (EM) CD8(+) T cells in peripheral blood contain two cell subsets with distinct traits that express low and high levels of the IL-7Rα. However, epigenetic mechanisms involved in defining such cellular traits are largely unknown. In this study, we use genome-wide DNA methylation and individual gene expression to show the possible role of DNA methylation in conferring distinct traits of chemotaxis and inflammatory responses in human IL-7Rα(low) and IL-7Rα(high) EM CD8(+) T cells. In particular, IL-7Rα(low) EM CD8(+) T cells had increased expression of CX3CR1 along with decreased DNA methylation in the CX3CR1 gene promoter compared with IL-7Rα(high) EM CD8(+) T cells. Altering the DNA methylation status of the CX3CR1 gene promoter changed its activity and gene expression. IL-7Rα(low) EM CD8(+) T cells had an increased migratory capacity to the CX3CR1 ligand fractalkine compared with IL-7Rα(high) EM CD8(+) T cells, suggesting an important biological outcome of the differential expression of CX3CR1. Moreover, IL-7Rα(low) EM CD8(+) T cells induced fractalkine expression on endothelial cells by producing IFN-γ and TNF-α, forming an autocrine amplification loop. Overall, our study shows the role of DNA methylation in generating unique cellular traits in human IL-7Rα(low) and IL-7Rα(high) EM CD8(+) T cells, including differential expression of CX3CR1, as well as potential biological implications of this differential expression.
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