ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Axl modulates immune activation of smooth muscle cells in vein graft remodeling.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Discoidin domain receptor 1 (DDR1): An emerged novel mechanosensor.Fundamental research · 2026Review
- From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis.Cell & bioscience · 2025Review
- Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Epigenome-Wide Changes in the Cell Layers of the Vein Wall When Exposing the Venous Endothelium to Oscillatory Shear Stress.Epigenomes · 2023Article
- AXL inhibitors selected by molecular docking: Option for reducing SARS-CoV-2 entry into cells.Acta pharmaceutica (Zagreb, Croatia) · 2022Article
- Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.Communications biology · 2021Article
- Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.The Journal of clinical investigation · 2021Article
- Review
- The Effect of Five-Day Dry Immersion on the Nervous and Metabolic Mechanisms of the Circulatory System.Frontiers in physiology · 2020Article
- The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.The American journal of pathology · 2019Article
- Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.British journal of pharmacology · 2019Article
- TAM receptors in cardiovascular disease.Cardiovascular research · 2019Review
- Review
- Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.The American journal of pathology · 2018Article
- Smooth muscle cells of human veins show an increased response to injury at valve sites.Journal of vascular surgery · 2018Article
- Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.Scientific reports · 2017Article
- Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The pathophysiological mechanisms of the immune activation of smooth muscle cells are not well understood. Increased expression of Axl, a receptor tyrosine kinase, was recently found in arteries from patients after coronary bypass grafts. In the present study, we hypothesized that Axl-dependent immune activation of smooth muscle cells regulates vein graft remodeling. We observed a twofold decrease in intimal thickening after vascular and systemic depletion of Axl in vein grafts. Local depletion of Axl had the greatest effect on immune activation, whereas systemic deletion of Axl reduced intima due to an increase in apoptosis in vein grafts. Primary smooth muscle cells isolated from Axl knockout mice had reduced proinflammatory responses by prevention of the STAT1 pathway. The absence of Axl increased suppressor of cytokine signaling (SOCS)1 expression in smooth muscle cells, a major inhibitory protein for STAT1. Ultrasound imaging suggested that vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1-SOCS1 balance in vein graft intima and progression of the remodeling. The results of this investigation demonstrate that Axl promotes STAT1 signaling via inhibition of SOCS1 in activated smooth muscle cells in vein graft remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.