ReviewMayo Clinic proceedings2015
Have Treatment Studies of Depression Become Even Less Generalizable? A Review of the Inclusion and Exclusion Criteria Used in Placebo-Controlled Antidepressant Efficacy Trials Published During the Past 20 Years.
Review in Mayo Clinic proceedings, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05734313 (Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression in Young Adults With Type 1 Diabetes), which is not on this map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression in Young Adults With Type 1 Diabetes
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Ineligibility for and Refusal to Participate in Randomized Controlled Trials That Have Studied Impact on Suicide-Related Outcomes in the United States: A Meta-Analysis.The Journal of clinical psychiatry · 2022Pooled it
- Pharmacological and somatic treatment effects on suicide in adults: A systematic review and meta-analysis.Depression and anxiety · 2022Pooled it
- Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants: A Systematic Review and Meta-analysis.JAMA psychiatry · 2022Pooled it
- Pooled it
- The Generalizability of Randomized Controlled Trials of Self-Guided Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms: Systematic Review and Meta-Regression Analysis.Journal of medical Internet research · 2018Pooled it
- Pooled it
- Treatments for Individuals with Suicidal Thoughts: Use, Indications, and Helpfulness.Journal of affective disorders reports · 2026Article
- Physiologically Based Pharmacokinetic (PBPK) Modeling of Antidepressants: A Scoping Review of Existing Models, Applications, and Software Tools.Clinical pharmacokinetics · 2026Article
- Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register-based study.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Article
- Real-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden.BMC psychiatry · 2024Article
- The future of psychopharmacology: a critical appraisal of ongoing phase 2/3 trials, and of some current trends aiming to de-risk trial programmes of novel agents.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Preference of Virtual Reality Games in Psychological Pressure and Depression Treatment: Discrete Choice Experiment.JMIR serious games · 2023Article
- Predicting non-response to multimodal day clinic treatment in severely impaired depressed patients: a machine learning approach.Scientific reports · 2022Article
- Design and Implementation of an Informatics Infrastructure for Standardized Data Acquisition, Transfer, Storage, and Export in Psychiatric Clinical Routine: Feasibility Study.JMIR mental health · 2021Article
- The significance of anxiety symptoms in predicting psychosocial functioning across borderline personality traits.PloS one · 2021Article
- Trends in (not) using scales in major depression: A categorization and clinical orientation.European psychiatry : the journal of the Association of European Psychiatrists · 2020Review
- Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials.BMC psychiatry · 2020Article
- Mean age and gender distribution of patients with major mental disorders participating in clinical trials.European archives of psychiatry and clinical neuroscience · 2020Article
- Symptom trajectories in the months before and after a suicide attempt in individuals with bipolar disorder: A STEP-BD study.Bipolar disorders · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the inclusion and exclusion criteria used in antidepressant efficacy trials (AETs) published during the past 5 years with those used in studies published during the previous 15 years. PATIENTS AND
methodsWe conducted a comprehensive literature review of placebo-controlled AETs published from January 1995 through December 2014. We included trials whether or not the medication has received regulatory approval for the treatment of depression. We compared the inclusion and exclusion criteria of studies published during the past 5 years (2010-2014) with those of studies published during the previous 15 years (1995-2009).
resultsWe identified 170 placebo-controlled AETs published during the past 20 years, 56 of which were published during the past 5 years. The more recent studies were significantly more likely to exclude patients with comorbid Axis I disorders and personality disorders, patients with the episode duration either too long or too short, and patients who had made a suicide attempt in the past. The severity threshold on depression rating scales required for inclusion was higher in the more recent studies.
conclusionThe inclusion and exclusion criteria of AETs have become more stringent over the past 5 years, thereby suggesting that AETs may be even less generalizable than they were previously (when concerns about their generalizability had already been raised).
Indexed as
Identifiers
26276679What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.