ArticleBlood2015
Autophagic vesicles on mature human reticulocytes explain phosphatidylserine-positive red cells in sickle cell disease.
Article in Blood, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 43 citations in OpenAlex.
- Protein S Enhances the Phagocytosis of Phosphatidylserine-Exposing Erythrocytes: Implications in Sickle Cell Disease.American journal of hematology · 2026Article
- Extracellular Vesicles in Sickle Cell Disease: A Promising Tool.Bioengineering (Basel, Switzerland) · 2022Review
- Measurement of erythrocyte membrane mannoses to assess splenic function.British journal of haematology · 2022Article
- ATG4A regulates human erythroid maturation and mitochondrial clearance.Blood advances · 2022Article
- Phenotypic analysis of erythrocytes in sickle cell disease using imaging flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022Article
- Reticulocyte Maturation.Membranes · 2022Review
- The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia.Annals of hematology · 2022Article
- Eryptosis as a New Insight in Malaria Pathogenesis.Frontiers in immunology · 2022Review
- A Systematic Survey of Characteristic Features of Yeast Cell Death Triggered by External Factors.Journal of fungi (Basel, Switzerland) · 2021Review
- Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.PLoS neglected tropical diseases · 2021Article
- Large red cell-derived membrane particles are major contributors to hypercoagulability in sickle cell disease.Scientific reports · 2021Article
- Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.Cellular microbiology · 2021Article
- Extracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy.International journal of molecular sciences · 2020Review
- Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections.PLoS neglected tropical diseases · 2020Article
- Not all red cells sickle the same: Contributions of the reticulocyte to disease pathology in sickle cell anemia.Blood reviews · 2020Review
- Autoimmune Anemia in Malaria.Trends in parasitology · 2020Review
- Therapeutic strategies for sickle cell disease: towards a multi-agent approach.Nature reviews. Drug discovery · 2019Review
- Cholesterol Deficiency Causes Impaired Osmotic Stability of Cultured Red Blood Cells.Frontiers in physiology · 2019Article
- A Conserved Requirement forFrontiers in physiology · 2019Article
- Non-muscle myosin II drives vesicle loss during human reticulocyte maturation.Haematologica · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles and reduce its surface area and volume. Here we show this involves a novel process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. Cell surface PS is a well-characterized apoptotic signal initiating phagocytosis. In peripheral blood from patients after splenectomy or in patients with sickle cell disease (SCD), the number of circulating red cells exposing PS on their surface is elevated. We show that in these patients PS is present on the cell surface of red cells in large (∼1.4 µm) discrete areas corresponding to autophagic vesicles. The autophagic vesicles found on reticulocytes are identical to those observed on red cells from splenectomized individuals and patients with SCD. Our data suggest the increased thrombotic risk associated with splenectomy, and patients with hemoglobinopathies is a possible consequence of increased levels of circulating mature reticulocytes expressing inside-out PS-exposed autophagic vesicles because of asplenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.