ArticleCell2015
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.
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Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 1 of them a synthesis that pooled it.
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190citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
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Who cites it
190 citing papers in PubMed, 1 synthesis or guideline pooled it, 313 citations in OpenAlex.
- Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing.PLoS neglected tropical diseases · 2022Pooled it
- Rapid and precise amplicon-based genome sequencing to preparedness and response chikungunya virus outbreaks.Emerging microbes & infections · 2026Article
- Lassa virus live tracking and lineage assignment: how nextstrain can enhance surveillance and public health in Africa and beyond.Emerging microbes & infections · 2026Article
- Lassa Virus-A Persistent and Evolving Threat.Microorganisms · 2026Review
- Decoding the human CD4Cell reports. Medicine · 2026Article
- Evaluating vectors for the design of a spillover-disrupting Lassa virus transmissible vaccine.PLoS computational biology · 2026Article
- Sequence to structure insights into Lassa virus population-level biophysical properties and glycoprotein structure catalogue.Npj viruses · 2026Article
- Site-1 protease mediated GPC processing is required for persistence of LCMV Clone 13.Npj viruses · 2026Article
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- Screening of the Pandemic Response Box Library Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target.Viruses · 2026Article
- Research Output and Global Trends in Lassa Fever: A 50-Year Bibliometric Analysis (1975-2025).BioMed research international · 2026Review
- Article
- A One Health trial design to accelerate Lassa fever vaccines.Nature medicine · 2026Article
- Genomic epidemiology and evolutionary analysis of Lassa virus from small mammals suggest bidirectional viral movement across humans and animals.Virus evolution · 2026Article
- Scaling Lassa Virus Dynamics within Anthropogenic Ecosystems (SCAPES) Study Protocol: a mixed-methods observational cohort study of humans, rodents, and landscapes in Nigeria.Wellcome open research · 2026Article
- Novel human coronavirus in an infant patient with pneumonia, Republic of Korea.Emerging microbes & infections · 2025Article
- Genome diversity and evolutionary understanding of Lassa virus: a holistic approach highlighting a potential target for cross-lineage vaccine development.Archives of virology · 2025Article
- Serological Evidence of Lassa Virus Exposure in Non-Viruses · 2025Article
- Robust polyfunctional CD8The Journal of general virology · 2025Article
- CLASV: Rapid Lassa virus lineage assignment with random forest.PLoS neglected tropical diseases · 2025Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
72 authors at 14 institutions in 4 countries.
Kristian G AndersenFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; The Scripps Research Institute, Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu.
B Jesse ShapiroFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Biological Sciences, University of Montréal, Montréal, QC H2V 2S9, Canada.
Christian B MatrangaBroad Institute, Cambridge, MA 02142, USA.
Rachel SealfonBroad Institute, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aaron E LinFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Lina M MosesTulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
Onikepe A FolarinInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria; Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Osun State, Nigeria.
Augustine GobaLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Ikponmwonsa OdiaInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Philomena E EhianeInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Mambu MomohLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone.
Eleina M EnglandBroad Institute, Cambridge, MA 02142, USA.
Sarah WinnickiFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Luis M BrancoZalgen Labs, Germantown, MD 20876, USA.
Stephen K GireFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Eric PhelanBroad Institute, Cambridge, MA 02142, USA.
Ridhi TariyalBroad Institute, Cambridge, MA 02142, USA.
Ryan TewheyFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Omowunmi OmoniwaInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Mohammed FullahLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone; Eastern Polytechnic College, Kenema, Eastern Province, Sierra Leone.
Richard FonnieLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Mbalu FonnieLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Lansana KannehLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Simbirie JallohLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Michael GbakieLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Sidiki SaffaLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Kandeh KarboLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Adrianne D GladdenBroad Institute, Cambridge, MA 02142, USA.
James QuBroad Institute, Cambridge, MA 02142, USA.
Matthew StremlauFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Mahan NekouiFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Hilary K FinucaneBroad Institute, Cambridge, MA 02142, USA.
Shervin TabriziFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
Joseph J VittiFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Bruce BirrenBroad Institute, Cambridge, MA 02142, USA.
Michael FitzgeraldBroad Institute, Cambridge, MA 02142, USA.
Caryn McCowanBroad Institute, Cambridge, MA 02142, USA.
Andrea IrelandBroad Institute, Cambridge, MA 02142, USA.
Aaron M BerlinBroad Institute, Cambridge, MA 02142, USA.
James BochicchioBroad Institute, Cambridge, MA 02142, USA.
Barbara Tazon-VegaBroad Institute, Cambridge, MA 02142, USA.
Niall J LennonBroad Institute, Cambridge, MA 02142, USA.
Elizabeth M RyanBroad Institute, Cambridge, MA 02142, USA.
Zach BjornsonDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA.
Danny A MilnerDepartment of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.
Amanda K LukensDepartment of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA.
Nisha BroodieCollege of Medicine, Columbia University, New York, NY 10032, USA.
Megan RowlandZalgen Labs, Germantown, MD 20876, USA.
Megan HeinrichZalgen Labs, Germantown, MD 20876, USA.
Marjan AkdagZalgen Labs, Germantown, MD 20876, USA.
John S SchieffelinTulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
Danielle LevyTulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
Henry AkpanNigerian Federal Ministry of Health, Abuja, Federal Capital Territory, Nigeria.
Daniel G BauschTulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
Kathleen RubinsThe National Aeronautics and Space Administration, Johnson Space Center, Houston, TX 77058, USA.
Joseph B McCormickThe University of Texas School of Public Health, Brownsville, TX 77030, USA.
Eric S LanderBroad Institute, Cambridge, MA 02142, USA.
Stephan GüntherDepartment of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20259 Hamburg, Germany.
Lisa HensleyNIAID Integrated Research Facility, Frederick, MD 21702, USA.
Sylvanus OkogbeninInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Viral Hemorrhagic Fever Consortium
Stephen F SchaffnerBroad Institute, Cambridge, MA 02142, USA.
Peter O OkokhereInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
S Humarr KhanLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
Donald S GrantLassa Fever Laboratory, Kenema Government Hospital, Kenema, Eastern Province, Sierra Leone.
George O AkpedeInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Danny A AsogunInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
Andreas GnirkeBroad Institute, Cambridge, MA 02142, USA.
Joshua Z LevinBroad Institute, Cambridge, MA 02142, USA.
Christian T HappiInstitute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria; Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Osun State, Nigeria. Electronic address: happic@run.edu.ng.
Robert F GarryTulane Health Sciences Center, Tulane University, New Orleans, LA 70118, USA.
Pardis C SabetiFAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: psabeti@oeb.harvard.edu.
Broad Institute · USIrrua Specialist Teaching Hospital · NGTulane University · USCenter for Systems Biology · USHarvard University · USZalgen (United States) · USBernhard Nocht Institute for Tropical Medicine · DEColumbia University · USFederal Ministry of Health · NGJohnson Space Center · USRedeemer's University · NGScripps Research Institute · USStanford University · USUniversité de Montréal · CA
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI CUOMO, CHRISTINA A · 2014 to 2024
$66.5MMechanistic Virology CoreU19AI109762 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI LAI, JONATHAN R. · 2014 to 2018
$29.6MElucidating Genetic Determinants of Resistance to Lassa Hemorrhagic FeverR01AI114855 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2015 to 2019
$3.8MHost and Pathogen Evolution in Lassa FeverDP2OD006514 · OD · HARVARD UNIVERSITY · PI SABETI, PARDIS CHRISTINE · 2010 to 2010
$2.5MMassively Parallel Phenotypic Characterization of Non-coding Genetic VariationK99HG008179 · NHGRI · HARVARD UNIVERSITY · PI TEWHEY, RYAN · 2015 to 2016
$220kNHGRI NIH HHS K99 HG008179NIAID NIH HHS HHSN272200900018CNIAID NIH HHS HHSN272200900049CNIAID NIH HHS HHSN272201000022CNIAID NIH HHS R01 AI114855NIAID NIH HHS U19 AI109762NIAID NIH HHS U19 AI110818NIAID NIH HHS U19AI110818NIH HHS 1DP2OD006514-01NIH HHS DP2 OD006514PHS HHS HHSN272200900018CPHS HHS HHSN272200900049CPHS HHS HHSN272201000022C
Abstract
The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.
Indexed as
Genome, ViralAfrica, WesternAnimalsBiological EvolutionDisease ReservoirsEbolavirusGenetic VariationGlycoproteinsHemorrhagic Fever, EbolaHumansLassa FeverLassa virusMurinaeMutationNigeriaRNA, ViralGlycoproteinsRNA, ViralViral Proteins
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