Evidence map›Paper›PMID 26276627›Full record

ReviewCell2015

Somatic Rearrangement in B Cells: It's (Mostly) Nuclear Physics.

Erez Lieberman Aiden, Rafael Casellas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Towards a predictive model of chromatin 3D organization.Seminars in cell & developmental biology · 2016
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erez Lieberman AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
Rafael CasellasGenomics and Immunity, NIAMS and NCI, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: rafael.casellas@nih.gov.

Funding

RAG and AID biologyZIAAR041148 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$44.8M
NIAMS Light Imaging FacilityZICAR041186 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI RANDAZZO, DAVIDE · 2010 to 2025
$18.2M
AID biologyZ01AR041148 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI CASELLAS, RAFAEL C · 2005 to 2008
$1.8M
Intramural NIH HHS Z01 AR041148
6 · The paper itself

Abstract

We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.

Indexed as

Gene Rearrangement, B-LymphocyteAnimalsB-LymphocytesCCCTC-Binding FactorCell NucleusHumansLymphocyte ActivationRepressor ProteinsV(D)J RecombinationCCCTC-Binding FactorCTCF protein, humanRepressor Proteins

Identifiers

PMID26276627
PMCPMC4537798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.