Evidence map›Paper›PMID 26276374›Full record

ReviewCytokine2015

Beyond Candida albicans: Mechanisms of immunity to non-albicans Candida species.

Natasha Whibley, Sarah L Gaffen

Abstract readReview
In one paragraph

Review in Cytokine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 54 citations in OpenAlex.

  1. Preventive action of ketamine alone and in combination with antifungals on Candida biofilm formation in catheters.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  2. Closing the Gap: Advances and Barriers onInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Drug susceptibility ofIranian journal of microbiology · 2026
    Article
  6. Article
  7. Comparative Evaluation ofBiomedicines · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The critical role of Dectin-1 in host controlling systemicAmerican journal of translational research · 2019
    Article
  17. The Role of IL-17 in Protection against Mucosal Candida Infections.Journal of fungi (Basel, Switzerland) · 2017
    Review
  18. Review
  19. Article
  20. Lactoferrin, chitosan and Melaleuca alternifolia-natural products that show promise in candidiasis treatment.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Natasha WhibleyDivision of Rheumatology & Clinical Immunology, Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Sarah L GaffenDivision of Rheumatology & Clinical Immunology, Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA; Division of Rheumatology & Clinical Immunology, BST S702, 200 Lothrop St., Pittsburgh, PA 15261, USA. Electronic address: sarah.gaffen@pitt.edu.
University of Pittsburgh · US

Funding

Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
IL-23/STAT3-Driven Oral Immune Responses to Candida albicansR01DE023815 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
Negative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
NIAID NIH HHS AI107825NIAID NIH HHS R01 AI107825NIDCR NIH HHS DE022550NIDCR NIH HHS DE023815NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R01 DE023815NIDCR NIH HHS R37 DE022550
6 · The paper itself

Abstract

The fungal genus Candida encompasses numerous species that inhabit a variety of hosts, either as commensal microbes and/or pathogens. Candida species are a major cause of fungal infections, yet to date there are no vaccines against Candida or indeed any other fungal pathogen. Our knowledge of immunity to Candida mainly comes from studies on Candida albicans, the most frequent species associated with disease. However, non-albicans Candida (NAC) species also cause disease and their prevalence is increasing. Although research into immunity to NAC species is still at an early stage, it is becoming apparent that immunity to C. albicans differs in important ways from non-albicans species, with important implications for treatment, therapy and predicted demographic susceptibility. This review will discuss the current understanding of immunity to NAC species in the context of immunity to C. albicans, and highlight as-yet unanswered questions.

Indexed as

AnimalsCandidaCandida albicansCandidiasisHumansCandida albicansFungal immunityNon-albicans species

Identifiers

PMID26276374
PMCPMC4573358
OpenAlexW1189511357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.