ArticleApplied and environmental microbiology2015
Anaerobic growth of Corynebacterium glutamicum via mixed-acid fermentation.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative characterization reveals conserved and divergent ecological traits of oral corynebacteria.Microbiology spectrum · 2026Article
- Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks.Nature communications · 2025Review
- Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- EngineeringBiodesign research · 2025Review
- Enhancement Strategy for Protocatechuic Acid Production UsingInternational journal of molecular sciences · 2025Article
- Microbial Corrosion of Copper Under Conditions Simulating Deep Radioactive Waste Disposal.Biology · 2024Article
- Two-stage conversion of syngas and pyrolysis aqueous condensate into L-malate.Biotechnology for biofuels and bioproducts · 2024Article
- High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered Corynebacterium glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions.Microbial cell factories · 2023Article
- A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum.Scientific data · 2022Article
- Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum.Metabolic engineering · 2021Article
- Physiological characteristics of Corynebacterium glutamicum as a cell factory under anaerobic conditions.Applied microbiology and biotechnology · 2021Review
- High-Quality Genome-Scale Reconstruction ofFrontiers in microbiology · 2021Article
- Disruption of the Oxidative Pentose Phosphate Pathway Stimulates High-Yield Production Using Resting Corynebacterium glutamicum in the Absence of External Electron Acceptors.Applied and environmental microbiology · 2020Article
- Lactic acid production - producing microorganisms and substrates sources-state of art.Heliyon · 2020Review
- Article
- COmBio · 2020Article
- The Expression of NOX From Synthetic Promoters Reveals an Important Role of the Redox Status in Regulating Secondary Metabolism ofFrontiers in bioengineering and biotechnology · 2020Article
- Recent advances of pH homeostasis mechanisms in Corynebacterium glutamicum.World journal of microbiology & biotechnology · 2019Review
- The copper-deprivation stimulon ofThe Journal of biological chemistry · 2018Article
- Metabolic engineering of Corynebacterium glutamicum for the production of cis, cis-muconic acid from lignin.Microbial cell factories · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Corynebacterium glutamicum, a model organism in microbial biotechnology, is known to metabolize glucose under oxygen-deprived conditions to l-lactate, succinate, and acetate without significant growth. This property is exploited for efficient production of lactate and succinate. Our detailed analysis revealed that marginal growth takes place under anaerobic conditions with glucose, fructose, sucrose, or ribose as a carbon and energy source but not with gluconate, pyruvate, lactate, propionate, or acetate. Supplementation of glucose minimal medium with tryptone strongly enhanced growth up to a final optical density at 600 nm (OD600) of 12, whereas tryptone alone did not allow growth. Amino acids with a high ATP demand for biosynthesis and amino acids of the glutamate family were particularly important for growth stimulation, indicating ATP limitation and a restricted carbon flux into the oxidative tricarboxylic acid cycle toward 2-oxoglutarate. Anaerobic cultivation in a bioreactor with constant nitrogen flushing disclosed that CO2 is required to achieve maximal growth and that the pH tolerance is reduced compared to that under aerobic conditions, reflecting a decreased capability for pH homeostasis. Continued growth under anaerobic conditions indicated the absence of an oxygen-requiring reaction that is essential for biomass formation. The results provide an improved understanding of the physiology of C. glutamicum under anaerobic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.