ArticleFertility and sterility2015
Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology.
Article in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Use of Chemical Hair Straighteners and Fecundability in a North American Preconception Cohort.American journal of epidemiology · 2023Article
- Subfertile patients underestimate their risk factors of reprotoxic exposure.Basic and clinical andrology · 2022Article
- Knowledge, Attitudes, and Behaviors Regarding Chemical Exposure among a Population Sample of Reproductive-Aged Women.International journal of environmental research and public health · 2022Article
- Pregnancy intention and phthalate metabolites among pregnant women in The Infant Development and Environment Study cohort.Paediatric and perinatal epidemiology · 2020Article
- Nonpersistent endocrine disrupting chemicals and reproductive health of women.Obstetrics & gynecology science · 2020Review
- The extent and predictors of phthalate exposure among couples undergoing in vitro fertilization treatment.Environmental monitoring and assessment · 2019Article
- Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility.Reproductive biology and endocrinology : RB&E · 2019Review
- Increased Urinary Phthalate Levels in Women with Uterine Leiomyoma: A Case-Control Study.International journal of environmental research and public health · 2016Article
- Racial/ethnic disparities in environmental endocrine disrupting chemicals and women's reproductive health outcomes: epidemiological examples across the life course.Current epidemiology reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine urinary phthalate metabolite concentrations in pregnant women with planned pregnancies in relation to history of infertility and use of assisted reproductive technology (ART).
designPhthalate metabolite concentrations were measured in first-trimester urine samples collected from women participating in a prospective pregnancy cohort study.
settingPrenatal clinics. PATIENT(S): A total of 750 women, of whom 86 had a history of infertility. Forty-one women used ART to conceive. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Primary outcomes were concentrations of four metabolites of diethylhexyl phthalate (DEHP) and their molar sum (∑DEHP). Multivariable analyses compared phthalate metabolite levels in [1] women reporting a history of infertility vs. those who did not (comparison group); and [2] those who used ART to conceive the index pregnancy vs. women with a history of infertility who did not use ART. RESULT(S): Among women with a history of infertility, ∑DEHP was significantly lower in women who conceived after ART compared with those who did not (geometric mean ratio: 0.83; 95% confidence interval 0.71-0.98). Similar significant associations were observed for all of the individual DEHP metabolites. There were no differences in DEHP metabolite concentrations between women with a history of infertility and the comparison group. CONCLUSION(S): Women who used ART to conceive had lower first-trimester phthalate metabolite concentrations than women with a history of infertility who did not use ART. Further research is needed to explore whether those pursuing fertility treatments take precautions to avoid exposure to environmental toxins, to improve treatment outcomes.
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Registered trials
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