ArticleBMC genomics2015
Evolutionary patchwork of an insecticidal toxin shared between plant-associated pseudomonads and the insect pathogens Photorhabdus and Xenorhabdus.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Genomic and functional analyses reveal Pseudomonas granadensis CT364 is a plant growth-promoting endophyte.BMC microbiology · 2025Article
- Enrichment of novel entomopathogenic Pseudomonas species enhances willow resistance to leaf beetles.Microbiome · 2024Article
- Gut microbiomes of cycad-feeding insects tolerant to β-methylamino-L-alanine (BMAA) are rich in siderophore biosynthesis.ISME communications · 2023Article
- Associated bacterial communities, confrontation studies, and comparative genomics reveal important interactions betweenFrontiers in fungal biology · 2023Article
- The genome of a steinernematid-associatedAccess microbiology · 2023Article
- Involvement of a novel Pseudomonas protegens strain associated with entomopathogenic nematode infective juveniles in insect pathogenesis.Pest management science · 2022Article
- Insecticidal features displayed by the beneficial rhizobacterium Pseudomonas chlororaphis PCL1606.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- The secret life of plant-beneficial rhizosphere bacteria: insects as alternative hosts.Environmental microbiology · 2022Review
- Root-Associated Bacteria Are Biocontrol Agents for Multiple Plant Pests.Microorganisms · 2022Review
- Phylogenetically closely related pseudomonads isolated from arthropods exhibit differential insect-killing abilities and genetic variations in insecticidal factors.Environmental microbiology · 2021Article
- Effects of Root-Colonizing Fluorescent Pseudomonas Strains onApplied and environmental microbiology · 2021Article
- IDOPS, a Profile HMM-Based Tool to Detect Pesticidal Sequences and Compare Their Genetic Context.Frontiers in microbiology · 2021Article
- Transcriptome plasticity underlying plant root colonization and insect invasion by Pseudomonas protegens.The ISME journal · 2020Article
- The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus.Nature communications · 2020Article
- T6SS contributes to gut microbiome invasion and killing of an herbivorous pest insect by plant-beneficial Pseudomonas protegens.The ISME journal · 2019Article
- Fitness Features Involved in the Biocontrol Interaction ofFrontiers in microbiology · 2019Review
- Recent trends of modern bacterial insecticides for pest control practice in integrated crop management system.3 Biotech · 2017Review
- Antimicrobial and Insecticidal: Cyclic Lipopeptides and Hydrogen Cyanide Produced by Plant-BeneficialFrontiers in microbiology · 2017Article
- Insect pathogenicity in plant-beneficial pseudomonads: phylogenetic distribution and comparative genomics.The ISME journal · 2016Article
- Characterization of Toxin Complex Gene Clusters and Insect Toxicity of Bacteria Representing Four Subgroups of Pseudomonas fluorescens.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoot-colonizing fluorescent pseudomonads are known for their excellent abilities to protect plants against soil-borne fungal pathogens. Some of these bacteria produce an insecticidal toxin (Fit) suggesting that they may exploit insect hosts as a secondary niche. However, the ecological relevance of insect toxicity and the mechanisms driving the evolution of toxin production remain puzzling.
resultsScreening a large collection of plant-associated pseudomonads for insecticidal activity and presence of the Fit toxin revealed that Fit is highly indicative of insecticidal activity and predicts that Pseudomonas protegens and P. chlororaphis are exclusive Fit producers. A comparative evolutionary analysis of Fit toxin-producing Pseudomonas including the insect-pathogenic bacteria Photorhabdus and Xenorhadus, which produce the Fit related Mcf toxin, showed that fit genes are part of a dynamic genomic region with substantial presence/absence polymorphism and local variation in GC base composition. The patchy distribution and phylogenetic incongruence of fit genes indicate that the Fit cluster evolved via horizontal transfer, followed by functional integration of vertically transmitted genes, generating a unique Pseudomonas-specific insect toxin cluster.
conclusionsOur findings suggest that multiple independent evolutionary events led to formation of at least three versions of the Mcf/Fit toxin highlighting the dynamic nature of insect toxin evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.