Trial reportSurgical endoscopy2016
Laparoscopic versus open surgery for complicated appendicitis in adults: a randomized controlled trial.
Trial report in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Pooled it
- Laparoscopic appendicectomy is superior to open surgery for complicated appendicitis.Surgical endoscopy · 2019Pooled it
- Laparoscopic versus open surgery for suspected appendicitis.The Cochrane database of systematic reviews · 2018Pooled it
- Systematic Review and Meta-Analysis of Laparoscopic Versus Open Appendicectomy in Adults with Complicated Appendicitis: an Update of the Literature.World journal of surgery · 2017Pooled it
- Single-instrument intracorporeal ligation versus polymer clip closure of the appendiceal stump in laparoscopic appendectomy: a prospective randomized study.BMC surgery · 2026Trial
- Is it necessary to use specimen retrieval bag for reducing surgical site infection in laparoscopic appendectomy?A randomized controlled trial.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Trial
- Laparoscopic versus open appendectomy for perforated appendicitis in adults: randomized clinical trial.Surgical endoscopy · 2020Trial
- Clinical significance of appendicoliths in conservative treatment of acute complicated appendicitis patients with peri-appendiceal abscess: a single-center retrospective study.Annals of medicine and surgery (2012) · 2024Article
- Clinical significance of peri-appendiceal abscess and phlegmon in acute complicated appendicitis patients undergoing emergency appendectomy.World journal of gastrointestinal surgery · 2024Article
- Association between body composition and incisional surgical site infection after laparoscopic appendectomy for complicated appendicitis.BMC surgery · 2024Article
- Colonoscopic titanium clipping to Maddress appendiceal stump leakage: a case report.Frontiers in surgery · 2023Article
- Challenges to implement laparoscopic appendectomy as the first-line treatment for acute appendicitis: a fifteen-year experience in a tertiary hospital in Brazil.Revista do Colegio Brasileiro de Cirurgioes · 2023Article
- Periappendiceal fluid collection on preoperative computed tomography can be an indication for interval appendectomy: a retrospective study.World journal of emergency surgery : WJES · 2022Article
- Partial cecum resection using endostapler in acute complicated appendicitis with appendiceal base necrosis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Article
- Transumbilical single-incision laparoscopic appendectomy with extracorporeal hand-sewn stump closure in adult patients.Fujita medical journal · 2021Article
- Cost-effectiveness analysis of initial nonoperative management versus emergency laparoscopic appendectomy for acute complicated appendicitis.BMC health services research · 2020Article
- A clinical comparison of laparoscopic versus open appendectomy for the treatment of complicated appendicitis: historical cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Observational
- Laparoscopic versus open approach for diffuse peritonitis from appendicitis ethiology: a subgroup analysis from the Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) study.Updates in surgery · 2020Article
- Are Preoperative CT Findings Useful for Predicting Postoperative Intraabdominal Abscess in the Patients with Acute Appendicitis?Medicina (Kaunas, Lithuania) · 2019Article
- Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.Surgical endoscopy · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess whether laparoscopic appendectomy (LA) for complicated appendicitis (CA) effectively reduces the incidence of postoperative complications and improves various measurements of postoperative recovery in adults compared with open appendectomy (OA).
methodsThis single-center, randomized controlled trial was performed in the Nagoya Daini Red Cross Hospital. Patients diagnosed as having CA with peritonitis or abscess formation were eligible to participate and were randomly assigned to an LA group or an OA group. The primary study outcome was development of infectious complications, especially surgical site infection (SSI), within 30 days of surgery.
resultsBetween October 2008 and August 2014, 81 patients were enrolled and randomly assigned with a 1:1 allocation ratio (42, LA; 39, OA). All were eligible for study of the primary endpoint. Groups were well balanced in terms of patient characteristics and preoperative levels of C-reactive protein. SSI occurred in 14 LA group patients (33.3 %) and in 10 OA group patients (25.6 %) (OR 1.450, 95 % CI 0.553-3.800; p = 0.476). Overall, the rate of postoperative complications, including incisional or organ/space SSI and stump leakage, did not differ significantly between groups. No significant differences between groups were found in hospital stay, duration of drainage, analgesic use, or parameters for postoperative recovery except days to walking.
conclusionThese results suggested that LA for CA is safe and feasible, while the distinguishing benefit of LA was not validated in this clinical trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.