Evidence map›Paper›PMID 26275438›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

A 2-year prospective densitometric study on the influence of Fok-I gene polymorphism in young patients with thalassaemia major.

M Dimitriadou, A Christoforidis, L Fidani, M Economou, E Vlachaki, M Athanassiou-Metaxa, G Katzos

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

M Dimitriadou1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece.
A Christoforidis1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece. christoforidis@doctors.org.uk.
L FidaniDepartment of General Biology, Medical School, Aristotle University, Thessaloniki, Greece.
M Economou1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece.
E VlachakiThalassaemia Unit, Ippokratio General Hospital, Thessaloniki, Greece.
M Athanassiou-Metaxa1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece.
G Katzos1st Paediatric Department, Aristotle University, 49, Konstantinoupoleos str, 54642, Thessaloniki, Greece.
Aristotle University of Thessaloniki · GRIppokrateio General Hospital of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThis study is to estimate the degree of genetic contribution of Fok-I gene polymorphism of Vitamin D receptor to bone mass in patients with thalassaemia. Results indicate a protective role of the f allele of the Fok-I gene polymorphism when found in homozygosity on bone mineral density of young thalassemic patients.

introductionThe purpose of this study is to estimate prospectively the degree of genetic contribution of Fok-I gene polymorphism of vitamin D receptor (VDR) to the evolution of bone mass in patients with beta-thalassemia major (b-TH).

methodsSixty-four children and young adults (33 males and 31 females) with mean decimal age of 23.20 ± 5.41 (range 9.25-32.41 years) were recruited in this study. All patients were genotyping for Fok-I gene polymorphism and were assessed with dual energy X-ray absorptiometry (DXA) at baseline and 2 years after. Z-scores were calculated based on normal age and sex matched Caucasian population. Metabolites of vitamin D, intact PTH, total calcium, inorganic phosphorous, and alkaline phosphatase were measured at the serum pre-transfusion.

resultsA moderate proportion of patients had decreased DXA Z-scores (Z-score ≤-2) predominately in total hip (31 %) and secondary in lumbar spine (15.6 %). Patients being homozygous for the f allele had apparently higher BMD Z-scores compared with those carrying the F allele in homo- or heterozygosity, however, with a difference that did not reached significance. Interestingly enough, a significant deterioration in BMD Z-scores measured at femur (FF: P = 0.004 Ff: P < 0.001, ff: P = 0.024) and total hip (FF: P = 0.022, Ff: P = 0.005) was recorded for all type of genotypes, except for ff genotype and with regard to the total hip DXA values. An increased prevalence of serum 25(OH)D3 deficiency (59.4 %) and 25(OH)D3 borderline (12.5 %) was recorded.

conclusionOur study indicates a protective role of the f allele of the Fok-I gene polymorphism when found in homozygosity on bone mineral density of young patients with b-TM.

Indexed as

Polymorphism, Single NucleotideAbsorptiometry, PhotonAdolescentAdultAnthropometrybeta-ThalassemiaBone DensityChildFemaleFemur NeckHip JointHumansLumbar VertebraeMaleProspective StudiesReceptors, CalcitriolReceptors, CalcitriolDual energy X-ray absorptiometryFok-I gene polymorphismThalassaemiaVitamin DVitamin D receptor

Identifiers

PMID26275438
OpenAlexW1128178892

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.