SynthesisPloS one2015
Measuring Health Utilities in Children and Adolescents: A Systematic Review of the Literature.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Measurement Properties of the EQ-5D Instruments in Children and Adolescents: A Systematic Review.Applied health economics and health policy · 2025Pooled it
- Economic Evaluations of Childhood Hearing Loss Screening Programmes: A Systematic Review and Critique.Applied health economics and health policy · 2019Pooled it
- A systematic review of utility values in children with cerebral palsy.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- Parent-child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain.European journal of pediatrics · 2025Trial
- A comparison of health-related quality of life between continuous ambulatory peritoneal dialysis and automated peritoneal dialysis in children with stage 5 chronic kidney disease in Thailand: a randomized controlled trial.Pediatric nephrology (Berlin, Germany) · 2025Trial
- Economic evaluation of regular transfusions for cerebral infarct recurrence in the Silent Cerebral Infarct Transfusion Trial.Blood advances · 2021Trial
- Association of Adverse Childhood Experiences With Health-Related Quality of Life and Quality-Adjusted Life-Years Among Adolescents in the United Kingdom: Findings From Two General Population Cohorts.Alpha psychiatry · 2026Article
- Accessing providers for co-occurring health and mental health disorders for children and youth in Ontario: an analysis of linked survey and administrative health data.BMC primary care · 2026Article
- EQ-5D-Y-3L population norms for children in Mainland China derived from a national survey 2023-2024.Health and quality of life outcomes · 2025Article
- Determining health-related quality of life among children with malaria in Kenya: does the choice of EQ-5D value set matter?Health and quality of life outcomes · 2025Article
- Child and youth chronic physical health conditions: a comparison of survey data and linked administrative health data in Ontario.BMC pediatrics · 2025Article
- Comparison of EQ-5D-Y-3L Utility Scores Using Nine Country-Specific Value Sets in Chinese Adolescents.PharmacoEconomics · 2025Article
- Modernizing Newborn Screening in the Genomic Era: Importance of Health-Related Quality of Life.PharmacoEconomics - open · 2024Article
- Effects of myopia on health-related quality of life in adolescents: a population-based cross-sectional causal empirical survey.BMJ open ophthalmology · 2024Article
- Cataloging health state utility estimates for Duchenne muscular dystrophy and related conditions.Health and quality of life outcomes · 2024Article
- Economic evaluations of medical devices in paediatrics: a systematic review and a quality appraisal of the literature.Cost effectiveness and resource allocation : C/E · 2024Review
- Development of a Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone Therapy in Children with Growth Hormone Deficiency: A GloBE-Reg Initiative.Hormone research in paediatrics · 2024Article
- Understanding the valuation of paediatric health-related quality of life: a qualitative study protocol.BMJ open · 2023Article
- The Cost-Effectiveness of a Dance and Yoga Intervention for Girls with Functional Abdominal Pain Disorders.PharmacoEconomics - open · 2023Article
- Psychometric performance of proxy-reported EQ-5D youth version 5-level (EQ-5D-Y-5L) in comparison with three-level (EQ-5D-Y-3L) in children and adolescents with scoliosis.The European journal of health economics : HEPAC : health economics in prevention and care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this review was to evaluate the use of all direct and indirect methods used to estimate health utilities in both children and adolescents. Utilities measured pre- and post-intervention are combined with the time over which health states are experienced to calculate quality-adjusted life years (QALYs). Cost-utility analyses (CUAs) estimate the cost-effectiveness of health technologies based on their costs and benefits using QALYs as a measure of benefit. The accurate measurement of QALYs is dependent on using appropriate methods to elicit health utilities.
objectiveWe sought studies that measured health utilities directly from patients or their proxies. We did not exclude those studies that also included adults in the analysis, but excluded those studies focused only on adults. METHODS AND
findingsWe evaluated 90 studies from a total of 1,780 selected from the databases. 47 (52%) studies were CUAs incorporated into randomised clinical trials; 23 (26%) were health-state utility assessments; 8 (9%) validated methods and 12 (13%) compared existing or new methods. 22 unique direct or indirect calculation methods were used a total of 137 times. Direct calculation through standard gamble, time trade-off and visual analogue scale was used 32 times. The EuroQol EQ-5D was the most frequently-used single method, selected for 41 studies. 15 of the methods used were generic methods and the remaining 7 were disease-specific. 48 of the 90 studies (53%) used some form of proxy, with 26 (29%) using proxies exclusively to estimate health utilities.
conclusionsSeveral child- and adolescent-specific methods are still being developed and validated, leaving many studies using methods that have not been designed or validated for use in children or adolescents. Several studies failed to justify using proxy respondents rather than administering the methods directly to the patients. Only two studies examined missing responses to the methods administered with respect to the patients' ages.
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