ArticlePLoS neglected tropical diseases2015
Development of Resistance to Pyrethroid in Culex pipiens pallens Population under Different Insecticide Selection Pressures.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Impact of combined vector control interventions on Anopheles gambiae sensu lato resistance dynamics in a high pyrethroid resistance settings in Southwestern Burkina Faso.Malaria journal · 2025Article
- Transcriptome and Functional Analyses Revealed the Carboxylesterase Genes Involved in Pyrethroid Resistance inInsects · 2025Article
- Chemical Exposure of Synthetic Pyrethroid on Deltamethrin Under the Selection Pressure over the Generations: A Reproductive Potential Study of Anopheles stephensi.Applied biochemistry and biotechnology · 2024Article
- Insecticide resistance reduces the profitability of insect-resistant rice cultivars.Journal of advanced research · 2024Article
- Isolation, characterization and functional analysis of a bacteriophage targeting Culex pipiens pallens resistance-associated Aeromonas hydrophila.Parasites & vectors · 2024Article
- The dynamics of deltamethrin resistance evolution in Aedes albopictus has an impact on fitness and dengue virus type-2 vectorial capacity.BMC biology · 2023Article
- Article
- Phenotypic resistance to pyrethroid associated to metabolic mechanism inWellcome open research · 2023Article
- Article
- A whole transcriptomic approach provides novel insights into the molecular basis of organophosphate and pyrethroid resistance in Anopheles arabiensis from Ethiopia.Insect biochemistry and molecular biology · 2021Article
- Experimental evolution supports the potential of neonicotinoid-pyrethroid combination for managing insecticide resistance in malaria vectors.Scientific reports · 2021Article
- The Differential Metabolic Profiles Between Deltamethrin-Resistant and -Susceptible Strains of Aedes albopictus (Diptera: Culicidae) by 1H-NMR.Journal of medical entomology · 2021Article
- Phenotypic, genotypic and biochemical changes during pyrethroid resistance selection in Anopheles gambiae mosquitoes.Scientific reports · 2020Article
- Lipase is associated with deltamethrin resistance in Culex pipiens pallens.Parasitology research · 2020Article
- First Report of Biochemical Mechanisms of Insecticide Resistance in the Field Population ofJournal of arthropod-borne diseases · 2019Article
- Trends in insecticide resistance in Culex pipiens pallens over 20 years in Shandong, China.Parasites & vectors · 2019Article
- Evaluation of Pyrethroid Susceptibility inJournal of arthropod-borne diseases · 2018Article
- ASGDB: a specialised genomic resource for interpreting Anopheles sinensis insecticide resistance.Parasites & vectors · 2018Article
- piRNA-3312: A Putative Role for Pyrethroid Resistance in Culex pipiens pallens (Diptera: Culicidae).Journal of medical entomology · 2017Article
- Genomic Analysis of Detoxification Supergene Families in the Mosquito Anopheles sinensis.PloS one · 2015Article
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
Abstract
Current vector control programs are largely dependent on pyrethroids, which are the most commonly used and only insecticides recommended by the World Health Organization for insecticide-treated nets (ITNs). However, the rapid spread of pyrethroid resistance worldwide compromises the effectiveness of control programs and threatens public health. Since few new insecticide classes for vector control are anticipated, limiting the development of resistance is crucial for prolonging efficacy of pyrethroids. In this study, we exposed a field-collected population of Culex pipiens pallens to different insecticide selection intensities to dynamically monitor the development of resistance. Moreover, we detected kdr mutations and three detoxification enzyme activities in order to explore the evolutionary mechanism of pyrethroid resistance. Our results revealed that the level of pyrethroid resistance was proportional to the insecticide selection pressure. The kdr and metabolic resistance both contributed to pyrethroid resistance in the Cx. pipiens pallens populations, but they had different roles under different selection pressures. We have provided important evidence for better understanding of the development and mechanisms of pyrethroid resistance which may guide future insecticide use and vector management in order to avoid or delay resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.