ArticlePloS one2015
Intraspecies Genomic Diversity and Long-Term Persistence of Bifidobacterium longum.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Enhancing the Adhesion/Colonization Efficacy of Probiotics by Polysaccharide Surface Decoration for Remission from Ulcerative Colitis.Probiotics and antimicrobial proteins · 2026Review
- Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.Nature communications · 2026Article
- Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria.Nature microbiology · 2025Article
- Modulation of Bifidobacterium by HD5 during weaning is associated with high abundance in later life.Communications medicine · 2025Article
- Integrative genomic reconstruction reveals heterogeneity in carbohydrate utilization across human gut bifidobacteria.bioRxiv : the preprint server for biology · 2025Article
- Comparative Genomic Analysis of NovelMicroorganisms · 2021Article
- Comparative Genomics Analyses Reveal the Differences betweenMicroorganisms · 2021Article
- Article
- Revisiting the Metabolic Capabilities ofMicroorganisms · 2020Article
- Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders.Frontiers in cellular and infection microbiology · 2020Article
- Comparative Pangenomics of the Mammalian Gut CommensalMicroorganisms · 2019Article
- Modeling the temporal dynamics of the gut microbial community in adults and infants.PLoS computational biology · 2019Article
- In Vitro Comparative Analysis of Probiotic and Functional Attributes of Indigenous Isolates of Bifidobacteria.Current microbiology · 2019Article
- Within-Species Genomic Variation and Variable Patterns of Recombination in the Tetracycline ProducerFrontiers in microbiology · 2019Article
- Long-term colonization exceeding six years from early infancy of Bifidobacterium longum subsp. longum in human gut.BMC microbiology · 2018Article
- Article
- Gene-trait matching across the Bifidobacterium longum pan-genome reveals considerable diversity in carbohydrate catabolism among human infant strains.BMC genomics · 2018Article
- Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan.Scientific reports · 2018Article
- Bifidobacteria and the infant gut: an example of co-evolution and natural selection.Cellular and molecular life sciences : CMLS · 2018Review
- Characterization and Exploitation of CRISPR Loci inFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of genus Bifidobacterium are Gram-positive bacteria, representing a large part of the human infant microbiota and moderately common in adults. However, our knowledge about their diversity, intraspecific phylogeny and long-term persistence in humans is still limited. Bifidobacterium longum is generally considered to be the most common and prevalent species in the intestinal microbiota. In this work we studied whole genome sequences of 28 strains of B. longum, including 8 sequences described in this paper. Part of these strains were isolated from healthy children during a long observation period (up to 10 years between isolation from the same patient). The three known subspecies (longum, infantis and suis) could be clearly divided using sequence-based phylogenetic methods, gene content and the average nucleotide identity. The profiles of glycoside hydrolase genes reflected the different ecological specializations of these three subspecies. The high impact of horizontal gene transfer on genomic diversity was observed, which is possibly due to a large number of prophages and rapidly spreading plasmids. The pan-genome characteristics of the subspecies longum corresponded to the open pan-genome model. While the major part of the strain-specific genetic loci represented transposons and phage-derived regions, a large number of cell envelope synthesis genes were also observed within this category, representing high variability of cell surface molecules. We observed the cases of isolation of high genetically similar strains of B. longum from the same patients after long periods of time, however, we didn't succeed in the isolation of genetically identical bacteria: a fact, reflecting the high plasticity of microbiota in children.
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