Trial reportPloS one2015
Association of Mucosal Organisms with Patterns of Inflammation in Chronic Rhinosinusitis.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review.American journal of rhinology & allergy · 2017Pooled it
- Comparison of Bacteriology Between Geriatric and Adult Rhinosinusitis with and Without NPs.Diagnostics (Basel, Switzerland) · 2025Article
- Epithelial innate immune response to Pseudomonas aeruginosa-derived flagellin in chronic rhinosinusitis.International forum of allergy & rhinology · 2023Article
- Comparison of mycology between different types of chronic rhinosinusitis.Journal of the Chinese Medical Association : JCMA · 2023Article
- Chronic Rhinosinusitis,Biomedicines · 2022Review
- Unraveling the role of the microbiome in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2022Review
- Sinus Microbiota in Patients With Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.Frontiers in cellular and infection microbiology · 2021Article
- [The impact of endoscopic sinus surgery on sinonasal microbiome of chronic rhinosinusitis with nasal polyps].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- [Role of nasal microbiome in chronic sinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
- Predictors of nasal bacterial culture rates in patients with chronic rhinosinusitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Pathogen and host genetics underpinning cryptococcal disease.Advances in genetics · 2020Review
- Intranasal Inoculation of Cryptococcus neoformans in Mice Produces Nasal Infection with Rapid Brain Dissemination.mSphere · 2019Article
- Inflammation and Endotyping in Chronic Rhinosinusitis-A Paradigm Shift.Medicina (Kaunas, Lithuania) · 2019Review
- Chronic rhinosinusitis in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria.The Journal of allergy and clinical immunology · 2019Article
- Temporal instability of the post-surgical maxillary sinus microbiota.BMC infectious diseases · 2018Article
- Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota.Scientific reports · 2018Article
- Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies.Microbiome · 2018Review
- Chronic Rhinosinusitis and the Evolving Understanding of Microbial Ecology in Chronic Inflammatory Mucosal Disease.Clinical microbiology reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic rhinosinusitis is a multifactorial process disease in which bacterial infection or colonization may play an important role in the initiation or persistence of inflammatory response. The association between mucosal bacteria presence and inflammatory patterns has only been partially explored.
objectiveTo demonstrate specific mucosal microorganisms possible association with inflammatory patterns.
methodsWe collected nasal polyps or sinus tissues from a clinical selection of six patient groups with defined sinus disease using tissue biomarkers. In the tissues, we detected bacteria using peptide nucleic acid fluorescence in situ hybridization (PNA-FISH).
resultsAfter reviewing a total of 115 samples (15-20 samples per group), the mucosal presence of Staphylococcus aureus was correlated with IL-5 and SE-IgE positive chronic rhinosinusitis with nasal polyps and nasal polyps from cystic fibrosis patients. Chronic rhinosinusitis without nasal polyps with TNFα >20 pg/ml was associated with the mucosal presence of Pseudomonas aeruginosa.
conclusionThis study identifies the relationship between intramucosal microbes and inflammatory patterns, suggesting that bacteria may affect the type of inflammation in chronic rhinosinusitis. Additional investigation is needed to further identify the nature of the relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.