ArticlePloS one2015
Age-Related Left Ventricular Changes and Their Association with Leukocyte Telomere Length in Healthy People.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study.Scientific reports · 2020Trial
- Heart Failure in Younger Adults in Africa: Evidence from the Ibadan Heart Failure Project.Research in heart yield and translational medicine · 2026Article
- Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.Open heart · 2025Article
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- Associations of Midlife Leukocyte Telomere Length With Measures of Left Atrial Function in Community-Dwelling Older Adults: The ARIC Study.Journal of the American Heart Association · 2025Observational
- Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging.Scientific reports · 2025Observational
- Immunometabolism in the Aging Heart.Journal of the American Heart Association · 2025Review
- Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome.The journal of cardiovascular aging · 2025Article
- M-Mode Echocardiography in Canine Veterinary Practice: A Comprehensive Review of Left Ventricular Measurements in 44 Different Dog Breeds.Animals : an open access journal from MDPI · 2023Review
- Low birth weight and reduced postnatal nutrition lead to cardiac dysfunction in piglets.Journal of animal science · 2023Article
- Global longitudinal strain and echocardiographic parameters of left ventricular geometry and systolic function in healthy adult Angolans: Effect of age and gender.Global cardiology science & practice · 2022Article
- Reference intervals for echocardiographic measurements in healthy Chihuahua dogs.The Journal of veterinary medical science · 2022Article
- Sarcomeric Gene Variants and Their Role with Left Ventricular Dysfunction in Background of Coronary Artery Disease.Biomolecules · 2020Review
- Left Ventricular Remodeling Patterns in Primary Healthcare.Arquivos brasileiros de cardiologia · 2020Article
- Correlation between left ventricular myocardial strain and left ventricular geometry in healthy adults: a cardiovascular magnetic resonance-feature tracking study.The international journal of cardiovascular imaging · 2019Article
- Caloric restriction improves the redox homeostasis in the aging male rat heart even when started in middle-adulthood and when the body weight is stable.Biogerontology · 2019Article
- Senescent cells: a therapeutic target for cardiovascular disease.The Journal of clinical investigation · 2018Review
- Association between cystatin C and heart failure with preserved ejection fraction in elderly Chinese patients.Zeitschrift fur Gerontologie und Geriatrie · 2018Article
- Cardiac aging and heart disease in humans.Biophysical reviews · 2017Review
- Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.GeroScience · 2017Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWith advancing age the left ventricle (LV) undergoes structural and functional changes, thereby creating the substrate for the development of diseases. One possible mechanism of the ageing heart is a cellular senescence. Leukocyte telomere length (LTL) is a marker of replicative ageing. The purpose of this study was to evaluate the structure and function of the LV in people of different ages free of cardiovascular diseases (CVD) and regular drug medication and to assess their relationship with LTL. We hypothesized that age-related changes in LV myocardium are associated with telomere length.
methodsThe study population consisted of 150 healthy, non-obese volunteers aged 28 to 78 years without history of CVD, significant deviations by 12-lead electrocardiogram and negative exercise test (treadmill stress test). All the participants underwent standardized transthoracic echocardiography using an available system (iE33; Philips). The LTL was measured by real-time quantitative polymerase chain reaction. We determined the relative ratio of telomere repeat copy number (T) to single-copy gene copy number (S).
resultsIn the older people there was a higher wall thickness than in the younger (1.03 ± 0.09 vs. 0.88 ± 0.10, p<0.01), whereas LV mass index was comparable between them (85.8 ± 15.40 vs. 83.1 ± 11.8, p = 0.20). There was a decrease in LV dimensions with advancing age (p<0.001). Older subjects had impairment in LV relaxation. LTL was associated with decreased E/A, Em/Am ratio (β = -0.323, p = 0.0001) after adjusting for age, sex and risk factors. There is no relation between the LTL and the structure of LV.
conclusionsOur data suggest that the ageing process leads to changes in LV structure and diastolic function and is linked with a phenotype of concentric LV remodeling. Telomere attrition is associated with age-related LV diastolic dysfunction. Telomere length appears to be a biomarker of myocardial ageing.
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