ArticleAmerican journal of respiratory and critical care medicine2015
Close Surveillance with Long-Term Follow-up of Subjects with Preinvasive Endobronchial Lesions.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 46 citations in OpenAlex.
- Evidence for non-mucinous pulmonary lesions with adenocarcinoma in situ morphology exceeding the current 3 cm WHO threshold.Virchows Archiv : an international journal of pathology · 2026Article
- Attention-based deep learning for analysis of pathology images and gene expression data in lung squamous premalignant lesions.Genome medicine · 2026Article
- Upregulation of an Epithelial miRNA Is Associated with Immune Evasion in Progressive Bronchial Premalignant Lesions.Cancer immunology research · 2026Article
- Real-Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Translating premalignant biology to accelerate non-small-cell lung cancer interception.Nature reviews. Cancer · 2025Review
- Treatment options and prognosis of patients with lung squamous cell cancer in situ: a comparative study of lung adenocarcinoma in situ and stage IA lung squamous cell cancer.Translational lung cancer research · 2023Article
- FocalThoracic cancer · 2023Article
- The actin cytoskeleton: Morphological changes in pre- and fully developed lung cancer.Biophysics reviews · 2022Review
- The promises and challenges of early non-small cell lung cancer detection: patient perceptions, low-dose CT screening, bronchoscopy and biomarkers.Molecular oncology · 2021Review
- Elevated T cell repertoire diversity is associated with progression of lung squamous cell premalignant lesions.Journal for immunotherapy of cancer · 2021Article
- Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non-small cell lung cancer.Molecular oncology · 2021Article
- Role of bronchoscopy in management of central squamous cell lung carcinomaAnnals of translational medicine · 2019Review
- Toward precision medicine based on the molecular landscape of carcinomaJournal of thoracic disease · 2019Article
- Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.Nature communications · 2019Article
- Image enhancement technology in bronchoscopy: a prospective multicentre study in lung cancer.BMJ open respiratory research · 2018Article
- Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.Molecular & cellular proteomics : MCP · 2017Article
- Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Epithelial cell migration as a potential therapeutic target in early lung cancer.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- White light, autofluorescence and narrow-band imaging bronchoscopy for diagnosing airway pre-cancerous and early cancer lesions: a systematic review and meta-analysis.Journal of thoracic disease · 2016Article
- SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.PLoS biology · 2016Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAutofluorescence bronchoscopy (AFB) and computed tomography (CT) enable lung cancer (LC) detection at the early (pre-)invasive stage. However, LC risk in patients with preinvasive endobronchial lesions is unclear.
objectivesTo assess LC incidence and identify potential risk determinants in patients with preinvasive lesions.
methodsIn our tertiary care referral center, 164 subjects with preinvasive lesions were monitored up to 12.5 years by repeated AFB and CT. Occurrence of LC was monitored. Clinical management depended on histological grade, with cancer patients receiving standard care. Potential risk determinants (smoking status, baseline histology, cancer history, and chronic obstructive pulmonary disease [COPD] status) were evaluated in relation to cancer occurrence, event-free survival (EFS), and overall survival (OS). MEASUREMENTS AND MAIN
resultsDuring surveillance (median of 30 mo, range 4-152) of 164 subjects with preinvasive lesions (80 high grade and 84 low grade at inclusion), 61 LCs were detected in 55 subjects (median time to event 16.5 mo). Twenty-three LCs (38%) were detected by CT, and 38 (62%) were detected by AFB. More cancers (36 of 61; 59%) developed from separate, rather than initial lesional sites. Subjects with high-grade lesions were more likely to be diagnosed with LC at the same or another site in the lungs than those with low-grade lesions (P = 0.03). Independent risk determinants for OS were previous curatively treated cancer and COPD (P ≤ 0.05).
conclusionsPresence of preinvasive lesions, especially high-grade lesions, may serve as LC risk markers. LCs occur both at preinvasive lesion sites and elsewhere in the bronchial epithelium or lung parenchyma. Prospective validation of biomarkers and randomized intervention studies are needed to determine optimal management strategies.
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